Assessing the Effect of Non-invasive Temporal Interference Electrical Stimulation on Epileptic Biomarker Suppression: Insights from Intracranial Recordings in Patients with Epilepsy
Abstract number :
1.273
Submission category :
3. Neurophysiology / 3E. Brain Stimulation
Year :
2024
Submission ID :
1000
Source :
www.aesnet.org
Presentation date :
12/7/2024 12:00:00 AM
Published date :
Authors :
Presenting Author: Floian MISSEY, PhD – International Clinical Research Center - FNUSA ICRC
Emma ACERBO, PhD – EMORY University
Adam Dickey, MD, PhD – Emory University
Daniel FABO, MD – INNSU
Martin Pail, MD, PhD – Institute of Scientific Instruments of the CAS, Brno, Czech Republic
Stanislas LAGARDE, MD – APHM
Romain CARRON, MD – APHM
Fabrice Bartolomei, MD, PhD – Timone Hospital, Marseille, France
Nigel Pedersen, MBBS – UC Davis
Robert Gross, MD, PhD – Rutgers New Jersey Medical School
Viktor Jirsa, PhD – AMU
Daniel Drane, PhD – Emory University
Milan Brázdil, MD, PhD – 1st Department of Neurology, Faculty of Medicine, Masaryk University and St. Anne´s University Hospital, Brno, Czech Republic – member of ERN EpiCARE
Adam Williamson, PhD – St. Anne's University Hospital Brno
Rationale: Medication-refractory focal epilepsy poses a significant challenge, with approximately 30% of patients ineligible for surgery due to the involvement of eloquent cortex in the epileptogenic network. For such patients with limited surgical options, electrical neuromodulation represents a promising alternative solution. In this study, we investigate the therapeutic potential of non-invasive temporal interference (TI) electrical stimulation on patients with epilepsy through the evaluation of intracerebral recordings: before, during, and after TI stimulation.
Methods: Thirteen patients implanted with stereoelectroencephalography (sEEG) depth electrodes, were subjected to TI stimulation (1.3kHz, 7kHz, and 9kHz with an offset frequency of 130Hz), targeting components of the epileptogenic network and the mesial temporal lobe (hippocampal region).
Results: Our results reveal a statistically significant average decrease of 60% in the total number of interictal epileptiform discharges (IEDs) in all sampled brain regions with TI stimulation. Interestingly, sham stimulation at 1kHz frequency demonstrated an impact on IEDs activity; however, this effect diminished with increasing sham frequency (at 5 and 9kHz), highlighting the potential selective impacts of carrier frequencies.
Conclusions:
Our findings underscore the potential application of TI in epilepsy, as an additional promising non-invasivebrain stimulation tool. It potentially offers new opportunities with the ability to target brain region response to electrical neuromodulation before committing to a deep brain stimulation or responsive neurostimulation implant.
Funding: A.W. received funding from the European Union’s Horizon Europe research and innovation programme under grant agreement No. 101101040 (TREATMENT) and No. 101088623 (EMUNITI). Efforts on this project for both Drs. Daniel Drane and Emma Acerbo were in part supported by grants received from the National institute of Neurological Disorders and Stroke (NINDS) of the National Institutes of Healthy (NIH) [R01NS088748].
Neurophysiology