Clinical Guidance

Keeping current on evidence-based clinical guidance is critical for epilepsy professionals to provide quality care to people with epilepsy.

This page provides links to information about AES processes for systematic review and clinical guidance development, as well as epilepsy-related resources such as guidelines, practice parameters, and other clinical guidance developed by AES, other societies, or collaboratively.

AES Clinical Practice Guideline Development Manual (2020)
This manual outlines principles and processes intended to guide AES-led workgroups in the development of high-quality clinical guidance products consistent with broadly-accepted, evidence-based principles and processes appropriate to the needs of the epilepsy clinical community.

AES Clinical Guidance in Development

• AES/ACNS Electrocorticography (ECoG) Systematic Review and Guideline
• AES/AAN/CNS Epilepsy Surgery Systematic Review and Guideline

Resources

Evidence-based Guidelines

• Evidence-Based Guideline: Treatment of Convulsive Status Epilepticus in Children and Adults: Report of the Guideline Committee of the American Epilepsy Society
  • Guideline for Treatment of Prolonged Seizures in Children and Adults 
  • A Treatment Algorithm that Comprises Three Phases of Treatment 
• Evidence-based Guideline: Management of First Unprovoked Seizure in Adults
• Evidence-based Guideline: Treatment of Parenchymal Neurocysticercosis
• Evidence-based Guideline: Evaluation and Management of Concussion in Sports
• Evidence-based Guideline: Vagus Nerve Stimulation for the Treatment of Epilepsy

Practice Parameters

• Practice Guideline Summary: SUDEP Incidence Rates and Risk Factors: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the American Epilepsy Society
• Practice Parameter update: Management issues for women with epilepsy - Focus on pregnancy: Obstetrical complications and change in seizure frequency
• Practice Parameter update: Management issues for women with epilepsy - Focus on pregnancy: Vitamin K, folic acid, blood levels, and breastfeeding
• Practice Parameter update: Management issues for women with epilepsy - Focus on pregnancy: Teratogenesis and perinatal outcomes
• Practice Parameter: Treatment of the child with a first unprovoked seizure
• Practice Parameter: Diagnostic assessment of the child with status epilepticus
• Practice Parameter: Evaluating an apparent unprovoked first seizure in adults
• Practice Parameter: Temporal lobe and localized neocortical resections for epilepsy

Additional Papers

• Antiepileptic Drug Selection for People with HIV/AIDS
• Treatment of New-onset Epilepsy
• Treatment of Refractory Epilepsy
• Use of serum prolactin in diagnosing epileptic seizures

Click here for other AAN epilepsy guidelines and practice parameters.