Changes in Interhemispheric Coherence After Total Corpus Callosotomy: A Scalp EEG Study in Children with Non-lesional Generalized Epilepsy
Abstract number :
2.45
Submission category :
9. Surgery / 9B. Pediatrics
Year :
2024
Submission ID :
10
Source :
www.aesnet.org
Presentation date :
12/8/2024 12:00:00 AM
Published date :
Authors :
Presenting Author: Takehiro Uda, MD, PhD – Osaka Metropolitan University Graduate School of Medicine
Vich Yindeedej, MD – Tammasat University Hospital
Yuta Tanoue, MD, PhD – Osaka Metropolitan University Graduate School of Medicine
Futoshi Shuto, MD – Osaka Metropolitan University Graduate School of Medicine
Shugo Nishijima, MD – Osaka Metropolitan University Graduate School of Medicine
Takeshi Inoue, MD – Osaka City General Hospital
Ichiro Kuki, MD, PhD – Osaka City General Hospital
Masataka Fukuoka, MD – Osaka City General Hospital
Megumi Nukui, MD – Osaka City General Hospital
Shin Okazaki, MD – Osaka City General Hospital, Osaka, Japan
Noritsugu Kunihiro, MD, PhD – Osaka City General Hospital
Ryoko Umaba, MD, PhD – Osaka City General Hospital
Takeo Goto, MD, PhD – Osaka Metropolitan University Graduate School of Medicine
Rationale: Coherence analysis in electroencephalography (EEG) allows measurement of the degree of consistency of amplitude
between pairs of electrodes. Theoretically, disconnective epilepsy surgery should decrease coherence between corresponding
areas. The study aimed to evaluate postoperative changes in interhemispheric coherence values after corpus callosotomy (CC).
Methods: Non-lesional, drug-resistant, generalized epilepsy patients who underwent total CC were retrospectively collected.
To evaluate coherence, we divided the scalp interictal EEG into “baseline” and “discharge” states after excluding periods with
artifacts. Interhemispheric coherence values were obtained between eight pairs of symmetrically opposite scalp electrodes
in six different frequency bands. We analyzed both pre- and postoperative EEG sessions and calculated the percentage of
difference (POD) in coherence values.
Results: We collected 13 patients and analyzed 2496 interhemispheric coherence values. Preoperative coherence values differed
significantly between baseline and discharge states (p = 0.0003), but postoperative values did not (p = 0.11). For baseline
state, coherence values were decreased after CC and median POD was − 22.3% (p < 0.0001). Delta frequency showed the
most decreased POD (-44.3%, p = 0.0009). Median POD was lowest in the Fp1-Fp2 pair of electrodes. For discharge state,
coherence values were decreased after CC and median POD was − 24.7% (p < 0.0001). Delta frequency again showed the
most decreased POD (-55.9%, p = 0.0016). Median POD was lowest in the F7-F8 pair.
Conclusions: After total CC, interhemispheric coherence decreased significantly in both baseline and discharge states. The
most decreased frequency band was the delta band, which may be used as a representative frequency band in future studies.
Funding: This work was supported by JSPS KAKENHI Grant Number JP22K09212.
Surgery