Clinical Features by Frequency of Seizures in Benign Convulsions with Mild Gastroenteritis: A Single-center Study
Abstract number :
2.225
Submission category :
4. Clinical Epilepsy / 4B. Clinical Diagnosis
Year :
2024
Submission ID :
34
Source :
www.aesnet.org
Presentation date :
12/8/2024 12:00:00 AM
Published date :
Authors :
Presenting Author: Young Ok Kim, MD, PhD – Chonnam National University Medical School
Rationale: Benign convulsion with mild gastroenteritis (CwG) is commonly characterized by cluster seizures. Although previous studies have compared the clinical characteristics of CwG patients by seizure frequency, data remain sparse. We sought to elucidate the clinical features of CwG in relation to seizure frequency.
Methods: This retrospective study included patients aged 3–36 months diagnosed with CwG at Chonnam National University Hospital between March 2005 and February 2024. Patients were categorized into 3 groups based on the number of seizures: single seizure (Group I), 2 seizures (Group II), and more than 3 seizures (Group III). Clinical, laboratory, and brain imaging data were compared across the 3 groups and between redefined groups (Group I vs. Groups II and III; Groups I and II vs. Group III).
Results: We enrolled 178 patients with CwG, comprising 97 females (54.5%). They were categorized into 3 groups: Group I (N = 50, 28.1%), Group II (N = 46, 25.8%), and Group III (N = 82, 46.1%). The median age was 17.5 months (IQR 14.8–22.0), with no significant age differences among groups. A past history of CwG was noted in 4 patients (2.2%), and 2 had a family history of CwG (1.1%). Enteric symptoms preceded seizures in 93.8% of cases. Vomiting occurred more frequently in 128 patients with >2 seizures (86.7%) compared to those with 1 seizure (72%, P = 0.020). Seizures mainly occurred in winter (48.3%). The median number of seizures was 2 (1–3). Of 128 patients with recurrent seizures, 12 (9.4%) had changes in seizure type. The interval between the first and last seizures varied between Group II and III for intervals of < 6 hours (69.6% vs. 35.4%, P = 0.000) and 13–24 hours (0% vs. 19.5%, P = 0.001). In total, 461 seizure episodes were reported: 50 in Group I, 92 in Group II, and 319 in Group III. Seizure duration and types differed significantly across the groups (P = 0.004 and P = 0.025, respectively), with the majority in Group III ceasing within 5 minutes (98.4% vs. 90% in Group I). Focal tonic-clonic or clonic seizures were only noted in Group II (N = 2) and Group I (N = 1). Norovirus GII was the primary pathogen identified in stool samples (60.7%). Significant differences were found in platelet and serum calcium levels between patients with <
Clinical Epilepsy