Concordance of Functional MRI Memory Task and Resting State Functional MRI Connectivity Used in Surgical Planning for Pediatric Temporal Lobe Epilepsy
Abstract number :
2.292
Submission category :
9. Surgery / 9B. Pediatrics
Year :
2022
Submission ID :
2204455
Source :
www.aesnet.org
Presentation date :
12/4/2022 12:00:00 PM
Published date :
Nov 22, 2022, 05:25 AM
Authors :
Jason Hauptman, MD, PhD – Seattle Children's Hospital; Diem Kieu Tran, MD – Seattle Children's Hospital; Andrei Poliakov, PhD – Seattle Children's Hospital; Seth Friedman, PhD – Seattle Children's Hospital
Rationale: Assessing memory is often critical in surgical evaluation, although difficult to assess in young children and in patients with variable task abilities. While obtaining interpretable data from task-based functional magnetic resonance imaging (fMRI) measures are common in compliant and awake subjects, it is not known whether functional connectivity MRI (fcMRI) data show equivalent results. If this were the case, it would have substantial clinical and research generalizability. To evaluate this possibility, we evaluated the concordance between fMRI and fcMRI data collected in a pre-surgical epilepsy cohort.
Methods: Task-based functional MRI data for autobiographical memory tasks and resting state functional connectivity MRI data were collected in epilepsy patients seen at Seattle Children’s Hospital between 2010-2017. To assess memory related activation and laterality, signal change in task-based measures were computed as a percentage of average BOLD signal over the defined regions of interest. Functional connectivity MRI data analysis was performed using 1000 Functional Connectomes Project scripts based and FSL software packages. Lateralization indices (LI) were estimated for activation and connectivity measures. The concordance between these two measures was evaluated using correlation and regression analysis.
Results: In this epilepsy cohort studied, we observed concordance between fMRI activation and fcMRI connectivity having a LI regression coefficient of 0.470 (P-value = 0.00076 and R2 of 0.221).
Conclusions: Previously published studies have demonstrated fMRI and fcMRI overlap between measures of vision, attention, and language. In our clinical sample, task-based measures of memory and analogous resting state mapping were similarly linked in pattern and strength. These results support the use of fcMRI methods as a proxy for task-based memory performance in pre-surgical subjects, perhaps including those that are more limited in their behavioral compliance. Future investigations to extend these results will be helpful to explore how the magnitudes of effect map onto neuropsychological performance and post-surgical behavioral changes.
Funding: Not applicable
Surgery