Database of White Matter Streamlines for Constructing Dynamic Tractography Atlases
Abstract number :
1.11
Submission category :
11. Behavior/Neuropsychology/Language / 11B. Pediatrics
Year :
2024
Submission ID :
725
Source :
www.aesnet.org
Presentation date :
12/7/2024 12:00:00 AM
Published date :
Authors :
Presenting Author: Aya Kanno, MD, PhD – Sapporo medical university
Kazuki Sakakura, MD, PhD – Rush University
Yu Kitazawa, MD, PhD – Yokohama City University
Hiroshi Uda, MD/PhD – Wayne State University
Ryuzaburo Kochi, MD, PhD – Wayne State University
Masaki Sonoda, MD, PhD – Yokohama City University
Min-Hee Lee, PhD – Wayne State University
Jeong-Won Jeong, PhD – Wayne State University
Aimee F. Luat, MD – Central Michigan University
Eishi Asano, MD/PhD – Wayne State University
Rationale: Dynamic tractography is a neuroimaging-neurophysiology multimodality technique that enables the animation of the spatiotemporal dynamics of intra- and inter-hemispheric neural communications through white matter pathways. Our goal was to generate a database of white matter streamlines that investigators can use to construct a whole-brain level dynamic tractography atlas. Using this white matter streamline template, we aimed to visualize the dynamics of functional connectivity modulations during a language task.
Methods: Using open-source MRI data from 1,065 healthy participants, we delineated each anatomical streamline directly connecting a pair of cortical regions across 62 ROIs within the Montreal Neurological Institute standard space. Two board-certified neurosurgeons visually validated each streamline to eliminate the risk of non-direct and biologically implausible white matter pathways. Combined with intracranial EEG data from 109 patients undergoing epilepsy surgery, we identified specific time windows and cortical regions showing high-gamma (70-110 Hz) amplitude augmentation during an auditory descriptive naming task. We then visualized event-related enhancement of functional connectivity, defined as simultaneous, significant, and sustained high-gamma amplitude augmentation between two cortical regions directly connected by a white matter streamline.
Results: A total of 719 intra-hemispheric and 89 inter-hemispheric streamlines were found to directly connect cortical ROIs. The resulting white matter streamline template allowed us to demonstrate event-related functional connectivity modulations. While patients listened to auditory stimuli, naming-related functional connectivity enhancements involved the callosal fibers between the superior temporal gyri and subsequently the left arcuate fasciculus between the superior temporal and posterior inferior/middle frontal gyri. During overt responses, naming-related functional connectivity enhancements involved the callosal fibers between the precentral gyri.
Conclusions: The dynamic tractography atlas derived from our white matter streamline template can visualize event-related functional connectivity modulations at the whole-brain level. This template has the potential to assist clinicians in neurosurgical planning and advance the study of network dynamics underlying cognitive functions and the propagation of epileptiform discharges. We plan to make this white matter streamline template and database available as open-source material, allowing investigators to construct their own dynamic tractography atlas in a personalized manner.
Funding: Japan-U.S. Brain Research Cooperation Program, JERF TENKAN 22102, The ITO Foundation, Cheiron-GIFTS2023 (to A.K.)
NIH R01 NS089659 (to J.J.).
NIH R01 NS064033 (to E.A.).
Behavior