Authors :
Presenting Author: Sofía Lucila Rodríguez Rivera, PhD – Hospital Zambrano Hellion, TecSalud, Tecnologico de Monterrey, Mexico
José Antonio Infante Cantú, PhD – Hospital Zambrano Hellion, TecSalud, Tecnologico de Monterrey, Mexico
Héctor R. Martínez, PhD – Hospital Zambrano Hellion, TecSalud, Tecnologico de Monterrey, Mexico
Enrique Caro Osorio, PhD – Hospital Zambrano Hellion, TecSalud, Tecnologico de Monterrey, Mexico
Fortino Salazar Salazar, PhD – Hospital Zambrano Hellion, TecSalud, Tecnologico de Monterrey, Mexico
Ricardo Caraza Camacho, PhD – Hospital Zambrano Hellion, TecSalud, Tecnologico de Monterrey, Mexico
Josafat Jonathan Sánchez Dueñas, PhD – Hospital Zambrano Hellion, TecSalud, Tecnologico de Monterrey, Mexico
Rationale:
Resective surgery of the anterior temporal lobe with amygdalohippocampectomy (ATLah) is an effective treatment for drug-resistant epilepsy of the temporal lobe with hippocampal sclerosis. However, this procedure risks linguistic and memory impairment depending on the hemispheric dominance for memory and language (Epilepsia 2002 Mar;43(3):283-91).
Objective: To explore the outcome of language and memory after resective surgery using anterior temporal lobectomy with amygdalohippocampectomy at a private tertiary hospital.
Methods:
This is a cross-sectional, retrospective, observational study. Inclusion criteria: The Weschler intelligence scale was applied. Descriptive statistics and chi-square (SPSS 12) were used to evaluate differences between hemispheric dominance and pre/post-operative cognitive performance.
Results:
8 patients. Mean age 26.3 years old (SD=9.69), range 11-38, 5 females (62%), 2 pediatric patients (25%). Focal seizures with impaired consciousness (n=7, 87.5%). Drug-resistant (n=7, 87.5%). Mood disorders (n=6, 75%). Number of anti-crisis drugs: 1 (n=1, 12.5%), 2 (n=4, 50%), 3 or more (n=3, 37.5%). Receptive language and verbal memory: 5 patients had no changes before and after surgery; 3 patients had changes before surgery, one improved, and 2 had an unfavorable prognosis. Hemispheric language dominance: left (n=7, 87.5%), right (n=1, 12.5%). Diagnosis-surgery time (mean=10 years). Laterality of resection: left/right: 50%/50%. Engel classification: 1 (n=4, 50%), 2 (n=4, 50%). We found an association between post-operative receptive language, verbal memory alterations, and left ATLah (p< 0.05).