Authors :
Jing Lu, MD – The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China
Presenting Author: Xiaoshan Wang, PhD – The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China
Rationale:
This study was designed to investigate the alterations in the entire brain functional connectivity（FC） networks in children with self-limited epilepsy with centrotemporal spikes (SeLECTS), and to explore the correlation between these neural networks modifications and cognitive impairment.
Methods:
Magnetoencephalography (MEG) data was recorded from 63 drug-naïve children with SeLECTS and 30 healthy controls (HC). Cognitive function of the children was assessed using the fourth edition of the Wechsler Intelligence Scale for Children (WISC-IV). Corrected amplitude envelope correlation (AEC-c) analysis was employed to estimate the oscillatory FC across 68 Desikan-Killiany cortical regions of the brain. The relationship between AEC-c and the index of WISC-IV was computed using Spearman's correlation analysis.
Results:
A decrease in FC was observed between the right lateral orbitofrontal cortex and the right pericalcarine in the delta band, the right entorhinal and the left rostral anterior cingulate in the theta band and between the right fusiform gyrus and the left inferior parietal gyrus in the gamma2 band (P< .05). Conversely, certain FC networks were found to be enhanced between the right fusiform gyrus and the left parahippocampal gyrus, as well as between the left insular gyrus and the left rostral anterior cingulate in the delta band and between the left postcentral gyrus and the right cuneus in the gamma1 band(P< .05). When it came to the relationship of FC and cognitive function, in the theta band, the Working Memory Index (WMI) scores was positively correlated with the AEC-c value between the right fusiform gyrus and the left parahippocampal gyrus (R = .26; p < .05); also in the theta band, the Processing Speed Index (PSI) scores was positively correlated with the AEC-c value between the left insular gyrus and the left rostral anterior cingulate (R = .26; p < .05); in the gamma1 band, there was a negative correlation between the Perceptual Reasoning Index (PRI) scores and the AEC-c value of the left postcentral gyrus and the right cuneus(R =-.27; p < .05).