Abstracts

Rationale: Epilepsy is a disease of the brain defined by two unprovoked (or reflex) seizures occurring >24 h apart. This disease has a significant negative impact on all areas of the patient's functioning, reducing the quality of life. Long-term epilepsy is accompanied by the development of hormonal and metabolic changes that lead to comorbid pathology. Comorbidity of epilepsy and neuroendocrine disorders is up to 2/3 of all cases. The combination of epilepsy and neuroendocrine disorders may be due to the consequences of organic brain damage, such as deep frontal and temporal lobes or reticular formation of the trunk involved in neuroendocrine regulation. In some cases, hormonal imbalance caused by neuroendocrine disorders serves as an epilepsy-inducing factor due to the epileptogenic effect of androgens, insulin and a number of other hormones. On the other hand, generalized seizures lead to increased secretion of prolactin by the adenohypophysis, which may cause the development of neuroendocrine disorders in patients with epilepsy. The purpose of this research is to study the features of hormonal changes in men 18-44 years with epilepsy.

Methods: In this study, we were used clinical anamnestic, neurological, biochemical methods (determination of hormones in blood serum). EEG and EEG video monitoring were used as screening methods.

Results: When examining 90 people after losing consciousness when determining the concentration of prolactin in the blood serum, it was found that only 40 patients (44%) have epileptic seizures. The remaining men (n=50; 56%) had non-epileptic paroxysmal conditions: conversion, withdrawal paroxysms, syncope, panic attacks, sleep disturbances. 16 men (40%) had low testosterone levels after a seizure. In 14 patients (35%), there was a violation of the release of follicle-stimulating and luteinizing hormones, which developed following the dysfunction of hypothalamic cells producing gonadotropin-releasing hormone. 10 men (25%) showed a decrease in testosterone levels while taking an antiepileptic drug, which can be manifested as a decrease in overall activity, mood, decreased libido, changes in bone density and other manifestations.

Conclusions: Symptoms of epilepsy in adult men are diverse. As the disease itself affects the general hormonal background of a man, so treatment with antiepileptic drugs affects hormonal changes in the body of a man.

Funding: Please list any funding that was received in support of this abstract.: The funding has not been received to support this thesis.