How Epilepsy Changes Brain Activity and the Differences of Responsiveness to Antiseizure Medications: A Microstate Analysis in Newly Diagnosed Epilepsy
Abstract number :
1.246
Submission category :
3. Neurophysiology / 3A. Video EEG Epilepsy-Monitoring
Year :
2024
Submission ID :
853
Source :
www.aesnet.org
Presentation date :
12/7/2024 12:00:00 AM
Published date :
Authors :
Presenting Author: Kailing huang, MD – West China Hospital, Sichuan University
Yingying Zhang, MD – West China Hospital, Sichuan University
Xiang Huang, MD – West China Hospital, Sichuan University
Yuming Li, MD – West China Hospital, Sichuan University
Dong Zhou, MD – West China Hospital, Sichuan University
Dongmei An, MD – West China hospital of Sichuan University
Rationale: To explore the difference of EEG microstates features between newly diagnosed epilepsy (NDE) patients and healthy control (HC), and between the seizure free (SF) group and non-seizure free (NSF) group after antiseizure medication (ASM).
Methods: ighty-nine NDE patients without drug use and 81 matched HCs who received video-EEG monitoring were included. After a minimum follow-up of one year, 56 NDE patients who take ASM regularly were classified into SF and NSF group. A 5.0 ± 0.5-min, 21-channel resting-state EEG without artifact were collected for microstate analysis. The global explained variance (GEV), mean duration (MD), time coverage (TC), and frequency of occurrence (FO) of each microstate were calculated and compared between groups.
Results: We found a shorter MD (Z = 9.411, p = 0.00) and TC (Z = 9.783, p = 0.000), and lower FO (Z = 9.312, p = 0.000) of microstate B, while a longer MD (C: Z = -4.953, p = 0.000; D: Z = -2.176, p = 0.030) and TC (C: Z = -5.218, p = 0.000; D: Z= -2.747, p = 0.006) and higher FO (C: Z = -5.365, p = 0.000; D: Z = -2.647, p =0.008) of microstate C and D in NDE group compared to HC group. The transition probability from microstate B to other microstates was increased (A: Z = 9.772, p = 0.000; C: Z = 6.316, p = 0.000; D: Z = 9.015, p = 0.000), and it was decreased from microstate C to other microstates (A: Z = -5.293, p = 0.000; B: Z = -4.841, p = 0.000; D: Z = -7.106, p = 0.000) in NDE group. In the SF and NSF group, SF group showed longer MD (Z = -2.894, p = 0.004), TC (Z = -2.878, p = 0.004), higher FO (Z = -2.779, p = 0.005) and increased transition probability from microstate A to other microstates (B: Z = -2.419, p = 0.016; C: Z = -2.238, p = 0.025; D: Z = -3.534, p = 0.000).
Conclusions: Changes in EEG microstate features were observed between NDE and HC, and between SF and NSF group after taking ASM, indicating that EEG microstate can well identify changes in brain activity and responsiveness to the ASM. Our study highlights the values of EEG microstates as a promising functional biomarker for epilepsy.
Funding: This study was supported by National Natural Science Foundation of China (NSFC Grants No. 82171443)
Neurophysiology