Patient Reported Outcomes in Patients with Brain Injuries and Seizures
Abstract number :
2.063
Submission category :
14. Neuropathology of Epilepsy
Year :
2024
Submission ID :
686
Source :
www.aesnet.org
Presentation date :
12/8/2024 12:00:00 AM
Published date :
Authors :
Presenting Author: Saba Saleem Qazi, MBBS – Massachusetts general hospital
Saiyid Ahmad Ali Naqvi, MBBS – Massachusetts General Hospital
Syed Ahsan, MBBS – Massachusetts General Hospital
Maria Donahue, MD – Massachusetts General Hospital
Lidia V.M.D. Moura, M.D., PhD, MPH – Massachusetts General Hospital
Marta Fernandes, PhD – Massachusetts General Hospital
Sahar Zafar, M.D., MSc – Massachusetts General Hospital
Sophia Iovieno, BS – Massachusetts General Hospital
Rationale: Brain injuries, including stroke and trauma, pose a significant risk of seizures and epilepsy, leading to debilitating physical and cognitive impairments. Despite the severity of these conditions, the patient experience and quality of life remain understudied. This investigation aimed to bridge this knowledge gap by examining the interplay between seizure management, antiseizure medication, and patient-reported outcomes (PROs) in individuals with brain injury and seizures.
Methods: A retrospective cohort study of 512 patients with brain injuries and seizures, seen in an epilepsy clinic between 2022 and 2024, was conducted. Patients completed PROs, including the Patient Reported Outcome Measure Information System (PROMIS-10) questionnaire, time since last seizure, and anti-seizure medication (ASM) adverse effects, as part of routine care.
Results: Anti-seizure medication (ASM) side effects were associated with worse patient reported outcomes (PROMIS-10) for mental (42.3 vs 48.3, p < 0.001) and physical (42.3 vs 50.8, p < 0.001) well-being. Additionally, brain injury patients with recent seizures had lower PROMIS-10 scores for mental (43.5 vs 52.0, p < 0.001) and physical (44.9 vs 50.8, p = 0.002) quality of life.
Neuropathology of Epilepsy