Risk Factors for Meningitis in Serological Tests in Children with Seizures Accompanied by Fever
Abstract number :
3.313
Submission category :
4. Clinical Epilepsy / 4B. Clinical Diagnosis
Year :
2024
Submission ID :
87
Source :
www.aesnet.org
Presentation date :
12/9/2024 12:00:00 AM
Published date :
Authors :
Presenting Author: Ki Taek Oh, – Wonju Severance Christian Hospital
Byung Ho Cha, MD, PhD – Wonju Severance Christian Hospital
Rationale: Febrile seizure is a seizure accompanied by fever (temperature >=38°C), without central nervous system infection, that occurs in infants and children 6 through 60 months of age. Menigitis should be considered in the differential diagnosis for any febrile seizure child, and lumbar puncture should be performed if the child is ill-appearing or if there are clinical signs or symptoms of concern.
But there is a lack of of evidence regarding which patients should undergo lumbar puncture except physical examination and clinical signs
So, we examined the serum laboratory study to identify another risk factors for meningitis in patients with a seizure accompanied by fever.
Methods: Patients who were visited Wonju Severance Christian Hospital due to a seizure accompanied by fever between 2017 and 2021 were identified. According to guideline of febrile seizure in American Academy of Pediatrics, from 6month to 60months of children were included and patients who were performed serum laboratory study and cerebrospinal fluid(csf) study were included.
Serum WBC, Hb, PLT, CRP, Na, K, Cl, CO2, Ca, Glucose, Ca, P, Mg, lactate were confirmed at the time of visting hospital
Meningitis is defined as csf WBC >5 or a confirmed pathogen(we checked pathogen through CSF culture, E.coli, H.influenza, L.monocytogenes, S.agalactiae, cytomegalovirus, enterovirus, HSV, HHV6, VZV polymerase chain reaction, PCR)
Febrile seizure is defined as seizure accompanied by fever without abnormal finding in csf study
Results: Total 217 patients were confirmed. 17were meningitis, 200 were febrile seizure. Among meningitis, 8 confirmed viral pathogen, 9 did not confirmed pathogen, but based on csf analysis they would be viral meningitis.
Compared to the febrile seizure, meningitis had statistically significantly higher potassium and calcium level (K 4.27±0.4 vs 4.57±0.47, p=0.004, Ca 9.57±0.56 vs 9.85±0.61, p=0.049)
Conclusions: In our study, there were statistically significantly differences in serum laboratory study between febrile seizure and meningitis. Further study will be needed why potassium and calcium affect seizure with fever who had viral meningitis in children.
Funding: none
Clinical Epilepsy