Scalp Fast Ripple as Non-invasive Biomarker of Epileptogenicity in Children
Abstract number :
2.108
Submission category :
3. Neurophysiology / 3A. Video EEG Epilepsy-Monitoring
Year :
2024
Submission ID :
1254
Source :
www.aesnet.org
Presentation date :
12/8/2024 12:00:00 AM
Published date :
Authors :
Emily Gost, BS – Lurie Children's Hospital
Mariana Vicenteno, AS, REEGT, CLTM – Lurie Children's Hospital
Khrystyna Moskalyk, BS, REEGT, NA-CLTM – Lurie Children's Hospital
Presenting Author: Joyce Wu, MD – Ann & Robert H Lurie Children's hospital of Chicago
Rationale: High frequency oscillation (HFO) has been shown to be a biomarker in epilepsy, and HFO detection on scalp EEG could further expand its utility as a non-invasive biomarker.
Methods: All video-EEGs (vEEGs) at a single-center pediatric epilepsy monitoring unit were acquired at 2048 Hz sampling rate, with a low pass/high frequency filter of 500 Hz. Artifact-free 10-minute sleep epochs were visually assessed in a blinded fashion for number of fast ripple events (FR; 250-500 Hz, 4 or more cycles), and compared to interictal spikes. Reasons for obtaining vEEGs were categorized as 1) diagnostic (seizure vs non-seizure), 2) therapeutic (seizure-free vs continued seizure with treatment), or 3) prognostic (continue vs discontinue medication). The seizure outcome was obtained after a minimum of one year follow up appointments.
Results: A total of 68 children (31 girls) met all above criteria, with average age of 7.5 years (SD 5.0 years, range 2 months to 19 years) at the time of vEEG. For the 19 diagnostic vEEGs, the accuracy of FR distinguishing seizure vs non-seizure was 84%, compared to 53% for spikes. For the 33 therapeutic vEEGs, FR accuracy in differentiating seizure-free vs continued seizures was 79%, compared to 67% for spikes. For the 16 prognostic vEEGs, FR accuracy in predicting seizure remission vs recurrence off anti-seizure medications was 100%, vs 44% for spikes.
Conclusions: Scalp FR may have utility as a diagnostic, therapeutic, and prognostic non-invasive biomarker in children. Further verification in larger groups are needed.
Funding: none
Neurophysiology