The Relationship Between Mood and Anxiety and Cognitive Phenotypes in Adults with Pharmacoresistant Temporal Lobe Epilepsy
Abstract number :
1.453
Submission category :
11. Behavior/Neuropsychology/Language / 11A. Adult
Year :
2023
Submission ID :
1252
Source :
www.aesnet.org
Presentation date :
12/2/2023 12:00:00 AM
Published date :
Authors :
First Author: Nolan Bingaman, n – Case Western Reserve University
Presenting Author: Kayela Arrotta, PhD – Cleveland Clinic
Lisa Ferguson, MA – Cleveland Clinic; Nicolas Thompson, MA – Cleveland Clinic; Anny Reyes, PhD – University of California, San Diego; Carrie McDonald, PhD – University of California, San Diego; Bruce Hermann, PhD – University of Wisconsin, Madison; Kayela Arrotta, PhD – Cleveland Clinic; Robyn Busch, PhD – Cleveland Clinic
Rationale:
Patients with temporal lobe epilepsy (TLE) are often at a high risk for cognitive and psychiatric comorbidities. Several cognitive phenotypes have been identified in TLE, but it is unclear how phenotypes relate to psychiatric comorbidities, such as anxiety and depression. This observational study investigated the relationship between cognitive phenotypes and psychiatric symptomatology in TLE.
Methods:
A total of 826 adults (age=40.3, 55% female) with pharmacoresistant TLE completed a neuropsychological evaluation that included at least two measures from five cognitive domains to derive International Classification of Cognitive Disorders in Epilepsy (IC-CoDE) cognitive phenotypes (i.e., intact, single-domain impairment, bi-domain impairment, generalized impairment). Participants also completed screening measures of depression and anxiety. Psychiatric history and medication data were extracted from electronic health records. Multivariable proportional odds logistic regression models examined the relationship between IC-CoDE phenotypes and psychiatric variables after controlling for relevant covariates.
Results:
Patients with elevated depressive symptoms had greater odds of demonstrating increasingly severe cognitive phenotypes than those without significant depressive symptomatology (odds ratios (OR)=1.123-1.993, all corrected p< 0.05; Figure 1). Number of psychotropic (OR=1.584, p< 0.05) and anti-seizure medications (OR=1.507, p< 0.001), use of anti-seizure medications with mood-worsening effects (OR=1.748, p=0.005), and history of a psychiatric diagnosis (OR=1.928, p< 0.05) also increased the odds of a more severe cognitive phenotype, while anxiety symptoms were unrelated.
Behavior