Chicago, IL ― A newly published AES clinical practice guideline in Epilepsy Currents provides clinicians with an evidence-based framework for the management of infantile epilepsy, addressing a critical need for standardized, high-quality care in this vulnerable population.
The guideline synthesizes current research and expert consensus to deliver actionable recommendations for infants aged one month to under 36 months diagnosed with new-onset or drug-resistant epilepsy.
Developed by a multidisciplinary work group of professionals in epilepsy as well as parent representatives, the guideline outlines comprehensive treatment strategies across three key domains: pharmacological therapies, dietary interventions, and surgical options. Recommendations are supported by detailed evidence profiles and implementation considerations to assist clinicians in decision-making and individualized patient care.
“Infantile epilepsy presents unique diagnostic and therapeutic challenges, and variability in care can significantly impact outcomes,” said guideline co-chair, Dr. Daniel Freedman, UT Health Austin Pediatric Neurosciences at Dell Children’s. “This guideline provides clinicians with clear, evidence-based recommendations to support timely, effective, and consistent treatment,” said co-chair, Dr. Elissa Yozawitz, The Children's Hospital at Montefiore.
The guideline emphasizes:
- Early and accurate diagnosis of epilepsy in infants
- Evidence-based selection of anti-seizure medications
- Early consideration of dietary therapies, particularly the ketogenic diet, in refractory epilepsy
- Prompt evaluation and referral for surgical intervention in appropriate cases of refractory epilepsy
By integrating pharmacologic, nutritional, and surgical strategies, the guideline aims to improve seizure control, optimize neurodevelopmental outcomes, and reduce variability in care.
The authors highlight the importance of multidisciplinary collaboration and individualized care planning, noting that early intervention is critical to improving long-term outcomes for infants with epilepsy.
The full guideline is available online at: https://journals.sagepub.com/doi/full/10.1177/15357597261433266