Accuracy of High-frequency Oscillations Recorded Intra-Operatively for the Seizure Onset Zone and Epileptogenic Zone
Abstract number :
3.03
Submission category :
1. Basic Mechanisms / 1C. Electrophysiology/High frequency oscillations
Year :
2021
Submission ID :
1825783
Source :
www.aesnet.org
Presentation date :
12/6/2021 12:00:00 PM
Published date :
Nov 22, 2021, 06:50 AM
Authors :
Shennan Weiss, MD, PhD - SUNY Downstate, Kings County Hospital; Richard Staba, PhD - UCLA; Zachary Waldman, MS - Thomas Jefferson University; Iren Orosz, MD - UCLA; Richard Gorniak, MD - Thomas Jefferson University; Ashwini Sharan, MD - Thomas Jefferson University; Chengyuan Wu, MD MS - Thomas Jefferson University; Gregory Worrell, MD PHD - Mayo Clinic; Jerome Engel, MD PhD - UCLA; Michael Sperling, MD - Thomas Jefferson University
Rationale: To see whether acute intraoperative recordings using stereo EEG (SEEG) electrodes can replace chronic intracranial EEG (iEEG) recording, making the process more efficient and safer.
Methods: Ten minutes of iEEG were recorded following electrode implantation in 16 anesthetized patients, and 3-4 days later during non-rapid eye movement (REM) sleep. Ripples on oscillations (RonO, 80-250 Hz), ripples on spikes (RonS), sharp-spikes i.e false HFOs 80-600 Hz, fast RonO (fRonO, 250-600 Hz), and fast RonS (fRonS) were detected. HFO rates in the SOZ and non-SOZ were compared using a two-way repeated measures ANOVA. A receiver operating curve (ROC) analysis was used for quantifying SOZ classification accuracy. HFO rates were also compared within the resection margins and compared with outcome.
Results: In both the intraoperative and non-REM sleep recordings, sharp-spikes and all HFO subtypes were increased in the SOZ (p< 0.01). However, the increases were larger during the non-REM sleep recordings (p< 0.05). The area under the ROC curves (AUROC) for SOZ classification were significantly smaller for intraoperative sharp-spikes, fRonO, and fRonS rates, compared to the AUROC of these biomarkers detected during non-REM sleep (p< 0.05).
Conclusions: Acute intraoperative SEEG recordings exhibit increased rates of sharp-spikes and HFOs in the SOZ, however recording these biomarkers during non-REM sleep offers a more accurate delineation of the SOZ.
Funding: Please list any funding that was received in support of this abstract.: 1K23NS094633.
Basic Mechanisms