Age at Onset and Drug Resistance in Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis
Abstract number :
2.276
Submission category :
4. Clinical Epilepsy / 4D. Prognosis
Year :
2024
Submission ID :
70
Source :
www.aesnet.org
Presentation date :
12/8/2024 12:00:00 AM
Published date :
Authors :
Presenting Author: Haiya Deng, Master Degree Candidate – The Seventh Affiliated Hospital, Sun Yat-sen University
Xiaowei Xu, PhD – The Seventh Affiliated Hospital, Sun Yat-sen University
Rationale: To analyze the drug-resistant of mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE) patients with different age at onset of epilepsy, and establish a reliable nomogram to predict drug-resistant epilepsy（DRE）development in MTLE-HS.
Methods: This study conducted a retrospective clinical analysis in 144 patients with MTLE and divided them into two groups: early age at onset of epilepsy (≤ 18 years old) and late age at onset of epilepsy (≥ 19 years old). The clinical features of each group were compared. Independent predictors of DRE were included in the final multivariable logistic regression, and a derived nomogram was built.
Results: 61.11% patients are drug-resistant. Patients with early onset (≤ 18 years old) had a higher rate of drug resistance (p= 0.002, 73.68% vs 47.06%) and a higher proportion of febrile seizures (p= 0.013, 42.11% vs 23.53%). There were no significant differences in epilepsy duration, gender, side of HS on MRI, family history, growth and development history, and the proportion of different etiologies between the two groups (all p > 0.05). Under the same etiology group, there was no difference in drug resistance rate among patients with different onset ages (all p > 0.05). The results of drug resistance analysis showed that the probability of drug resistance was 0.94 times higher for every 1 year increase in the age of onset. The history of febrile seizures was a risk factor for drug resistance (OR= 2.787), and the age of onset was an independent risk factor for drug resistance (OR= 0.946). With the increase of disease duration, the drug resistance rate increased first and then decreased. As the age of onset increase, the total number of Antiseizure medications (ASMs) used decrease.
Conclusions: MTLE-HS patients with earlier age at epilepsy onset have a higher rate of drug resistance and a higher rate of history of febrile seizures. With the increase of age at onset, the drug resistance rate and the total number of ASMs used decreased.
Funding: No funding.
Clinical Epilepsy