Abstracts

Rationale: The malformations of cortical development (MDC) represent a heterogeneous group of disorders characterized by an abnormal proliferation and neuronal and glial migration, as well as disorder in the cortical organization, the MCD are present in 68% of the infants and 26 % of the adultsMethods: In the present work we include two groups of patients from those who the sample was obtained in surgery to be refractory to pharmacological treatment; adults with MDC (with dual pathology) and infants with epilepsy of the denominated catastrophic epilepsies. Neurocitological analysis was made at level of confocal microscopy, electronic and light microscopyResults: The results showed in agreement with the classification of Palmini et al. (2004) a greater percentage (50%) of the patients with displasia focal cortical (FCD) type I, abnormalities in the cytoarchitecture, with giant neurons, 20% type IB that involve dyslamination and giant neurons, 22% FCD type IIB abnormalities in the cytoarchitecture and dismorphic neurons and some balloon cells and 8% with hemimegancefaly, characterized by immature cells strongly positive to nestin and vimentin antibody. Nevertheless, in the some cases the pyramidal neurons show a good preservation and distribution of the dendrite spines mainly the infants. Conclusions: The results indicate that MDC is a common cause of refractory epilepsy. FCD type I is the predominant pathologic subtype in adults. This work was supported by the IMSS-2005/1/I/147, CONACYT-45943M grants.