Authors :
Presenting Author: Taneeta Ganguly, MD – University of Pennsylvania
holly Fontenot, MT, CCRA – Epiminder Ltd
Colin Ellis, MD – University of Pennsylvania
Erin Conrad, MD, MA – University of Pennsylvania
Udaya Seneviratne, MD, PhD – University of Melbourne
Alan Lai, PhD – University of Melbourne
Karen McLean, PhD – St. Vincent's Hospital
Andrew Niemiec, BSc, BE – Epiminder Ltd
Tracy Cameron, BSc, MS – Epiminder Ltd
Mark Cook, MD, PhD – St Vincent's Health, Australia
Rationale:
This study aimed to determine whether the Minder implantable Continuous EEG Monitoring (iCEM) system provides signal quality comparable to conventional scalp EEG. Signal quality and noise levels were assessed by blinded expert reviewers. Comparable EEG signals were further evaluated using spectral coherence analysis and Pearson’s correlation coefficients between Minder and scalp EEG recordings.
Methods:
The Minder system was implanted for continuous EEG recording. Signal comparisons were conducted during two 7-day co-monitoring periods using standard 10–20 scalp electrodes at 4 and 24 weeks post-implantation. Recordings were evaluated for spontaneous brain activity and subject-generated artefacts. Board-certified US electrophysiologists rated signal quality and reviewed seizure and non-seizure activity across both modalities. The protocol was approved by the St Vincent’s Hospital Melbourne HREC (HREC158/19) and registered (ACTRN12619001587190).
Results:
During co-monitoring, both scalp EEG and Minder detected physiological sleep spindles and epileptiform activity (interictal discharges and seizures). Expert reviewers rated signal quality and noise levels from the Minder system as comparable to scalp EEG, with no statistically significant differences on t-tests at 4 and 24 weeks. Spectral coherence analysis confirmed no significant differences in bandwidth, particularly within the clinically relevant 1–40 Hz range. Pearson’s correlation coefficients between Minder and scalp EEG signals were strongly associated with expert-derived signal quality and noise ratings, supporting inter-modality agreement.
Conclusions:
This study validates the reliability of the Minder iCEM system for long-term seizure monitoring. Comparable signal quality, spectral coherence, and correlation with standard scalp EEG recordings support its use in clinical care for patients with epilepsy.
Funding:
This study was funded by Epiminder Ltd.