Association between generalized polyspike train and drug-resistant idiopathic generalized epilepsy
Abstract number :
46
Submission category :
3. Neurophysiology / 3C. Other Clinical EEG
Year :
2020
Submission ID :
2422395
Source :
www.aesnet.org
Presentation date :
12/5/2020 9:07:12 AM
Published date :
Nov 21, 2020, 02:24 AM
Authors :
Erin Conrad, University of Pennsylvania; Nanak Chugh - University of Pennsylvania; Taneeta Ganguly - University of Pennsylvania; James Gugger - University of Pennsylvania; Etsegenet Tizazu - University of Pennsylvania; Russell Shinohara - University of Pe
Rationale:
To test the hypothesis that the recently-described [1, 2] EEG feature generalized polyspike train is associated with drug-resistant idiopathic generalized epilepsy.
Method:
We conducted a single-center retrospective analysis of patients with idiopathic generalized epilepsy who had outpatient EEGs performed between 2016 and 2020. We classified patients as drug-resistant or drug-responsive based on clinical review. We reviewed EEG data for the presence and timing of generalized polyspike train (a burst of generalized rhythmic spikes lasting less than 1 second). We tested for a relationship between generalized polyspike train and drug-resistance before and after controlling for EEG duration. We also calculated the EEG duration required to observe generalized polyspike train.
Results:
We included 102 patients (69% drug-responsive and 31% drug-resistant). Generalized polyspike train was non-significantly more prevalent in drug-resistant IGE (OR = 3.0, 95% CI 1.0-9.2, p = 0.07). This finding persisted when controlling for EEG duration both with stratification and survival analysis. A median of 5.1 hours (interquartile range 0.4-13.3 hours) of EEG recording was required to capture the first occurrence of generalized polyspike train.
Conclusion:
The presence of generalized polyspike train may predict drug-resistant idiopathic generalized epilepsy. Prolonged EEG recording is likely required to identify this feature.
1. Sun Y, Seneviratne U, Perucca P, et al. Generalized polyspike train: An EEG biomarker of drug-resistant idiopathic generalized epilepsy. Neurology. 2018;91:e1822–e1830.
2. Jensen CD, Gesche J, Krøigård T, Beier CP. Prognostic value of generalized polyspike trains and prolonged epileptiform EEG runs. J Clin Neurophysiol [online serial]. Epub 2019. Accessed at: http://dx.doi.org/10.1097/WNP.0000000000000679.
Funding:
:NA
Neurophysiology