Abstracts

Rationale: Rationale: It is unclear which patients with PLEDS will have associated seizures. For the management of these individuals it would be a very helpful to have information to guide in the decision of which patients need to be treated aggressively with anti-epileptic medications.Methods: Method: We present a prospective observational study of 8 consecutive non-anoxic patients with PLEDS on their continuous EEG monitoring. The EEG monitoring was for 24 hours duration. 4 of the patients had seizures associated with the PLEDS on their EEG and 4 of them had PLEDS but no seizures on their EEG. The etiology was neoplasm in 1 patient, cortical dysplasia in 1 patient, acute head trauma in 1 patient, encephalomalacia related to healed abscess in 1 patient. There was no structural lesion seen in the other 4 patients. All patients had brain MRI.Results: Results: We found that the 4 patients, who had seizures with PLEDS on their continuous EEG, had restricted diffusion on diffusion-weighted imaging in their MRI brain. The 4 patients who had PLEDS but no seizures on their continuous EEG, did not show a restricted diffusion pattern on diffusion-weighted imaging in their MRI brain.Conclusions: Conclusion: This is an ongoing study and it would be interesting to see if this is a consistent finding and if restricted diffusion in MRI brain can be used as a marker to identify patients with PLEDS on their EEG who are likely to have associated seizures.