Authors :
Presenting Author: Negin Badihian, MD – Cleveland Clinic Foundation
Nicolas Thompson, MSN – Neurological Institute
Vineet Punia, MD – Cleveland Clinic, Cleveland, OH, USA
Rationale:
Seizure-related features in epilepsy evolve over the lifespan. Aging often brings comorbidities which may also influence these characteristics. We aimed to assess the association of aging with the ictal and postictal seizure-related features, and to determine comorbidities’ impact on these features.
Methods:
We used the Liverpool Seizure Severity Scale (LSSS), filled out as part of outpatient clinic visit, at the Cleveland Clinic Epilepsy Center between 08/2007 and 03/2025. LSSS consists of 12 items and one dimension that assess characteristics of patient’s most severe seizure during the past 4 weeks. Higher total and item scores indicate greater severity of the seizure and its related features. We extracted Charlson comorbidity index (CCI), and epilepsy types based on ICD9/10. We categorized epilepsy types to focal, generalized and unknown. We utilized multivariable linear regression for LSSS total score and proportional odds logistic regression for LSSS items. Analyses were performed in R, version 4.3.1 and p-values < 0.05 were considered statistically significant.