CHANGES OF SEIZURE THRESHOLD IN THE TRANSIENT BILATERAL CAROTID ARTERY OCCLUSION IN GERBIL
Abstract number :
2.086
Submission category :
Year :
2003
Submission ID :
2233
Source :
www.aesnet.org
Presentation date :
12/6/2003 12:00:00 AM
Published date :
Dec 1, 2003, 06:00 AM
Authors :
Ki-Young Jung, Seong-Ho Park, Hee-Dong Park, Jae-Moon Kim Neurology, Samsung Medical Center, Seoul, Republic of Korea; Neurology, Seoul National University Bundang Hospital, Seongnam, Republic of Korea; Neurology, Chungnam National University Hospital, Da
Cerebral infarction may causes acute seizures. To determine whether the relapsed time after the cerebral infarction and duration of cerebral infarction alter the seizure threshold, we used transient internal carotid occlusion(ICA) model in Gerbil.
60-80 grams of male Gerbil was used in this study. ICA was transiently occluded for two and five minutes.(29 and 27 Gerbils each) After the ICA occlusion, seizure threshold was evaluated with flurothyl in day 1, 7, and week 4.
Seizure threshold (onset time of seizure after fluothyl exposure) was decreased in both groups compared with normal control in day 1, 7, and 4 weeks but was more prominent in 5 minutes than 2 minutes of ICA occlusion in day 1 and day 7(p[lt]0.05). In week 4 groups, seizure threshold was not significantly different between 2 minutes and five minutes of ICA occlusion. Acutely decreased seizure threshold in day 1 and 7 was partly normalized in 4 weeks after the ICA occlusion.
Severity of cerebral infarction affects seizure threshold and acute infarction (day 1 and 7) causes reduced seizure threshold in ICA occlusion model of Gerbil.