Abstracts

Rationale: Febrile seizures (FS) are the most common type of seizures observed among children. After the 1st FS, about 30% of the patients experience recurrent FS and 2 ~7 % of them were found with epilepsy. We investigated the risk factors related to recurrent febrile seizures. Methods: A retrospective study was conducted on 278 children with FS, who were admitted to the Pediatric Department of Wonju Severance Christian Hospital between January of 2010 and December of 2011. We compared the clinical characteristics between the children with recurrent (R group) and without recurrent (NR group) febrile seizures for the risk factors of recurrence of febrile seizures. Results: 99 children (36%) had experienced two more recurrent febrile seizures. The age of onset of R group was 30.7 20.2 months; NR group, 25.6 16.6 (p=0.031). The sex ratio of male and female was 1.9 : 1 in R group, but in NR group was 1.06 : 1 (p=0.005). The recurred febrile seizures within 24 hours after initial febrile seizure were 8.0% in R group; 3.1% in NR group (p=0.06). The delayed development were 1.04% in R group; 3% in NR group. The family history of febrile seizure in R group was 38.4 %; in NR group, 27.3%. the past history of perinatal asphyxia or trauma in R group was 12%; in NR group, 8.9%. The serum sodium in R group was 137.0 2.3; in NR group 135.6 2.5. The serum magnesium were 1.98 0.2 in R group; 1.94 0.2 in NR group. The serum glucose were 107.3 26.0 in R group; 107.3 26.0; 109.2 25.5 in NR group. The serum ammonia were 43.0 21.8 in R group; 43.2 24.9 in NR group Among the recurrent febrile seizure patient, 10.1 % had experienced six or more FS recurrences and onset age were older in more frequent group (p= 0.001), familial history of FS and complex type of FS is related to more instances of recurrent FS. Patients with short durations between the first and the second attack of febrile seizure tended to suffer more instances of recurrent FS although the statistical indication was not significant (p=0.642) Conclusions: The recurrent rate of febrile seizure was 36%. The male and older onset of age were more prone to recurrence of febrile seizure. The family history of febrile seizure was more common in the recurrent febrile patients, especially more frequent recurrent (more than 6 recurrence) patient. The other clinical characteristics were not related to recurrence of febrile seizure