COGNITIVE EVENT-RELATED POTENTIALS IN EPILEPSY PATIENTS
Abstract number :
1.101
Submission category :
Year :
2002
Submission ID :
48
Source :
www.aesnet.org
Presentation date :
12/7/2002 12:00:00 AM
Published date :
Dec 1, 2002, 06:00 AM
Authors :
Kwangsoo Kim, Bong-Goo Yoo, Kyung-Moo Yoo. Department of Neurology, Kosin University College of Medicine, Busan, Korea; Department of Neurology, Kosin University College of Medicine, Busan, Korea; Department of Neurology, Kosin University College of Medic
RATIONALE: Epilepsy and antiepileptic drugs may be associated with cognitive dysfunction. P300 event-related potentials have been used to assess cognitive function. In this study we investigate the effects of epilepsy and antiepileptic drugs on cognitive function in patients with epilepsy and evaluate the diagnostic value of P300 event-related potentials for cognitive dysfunction.
METHODS: P300 latency in event-related potentials was recorded during an auditory oddball paradigm in 29 patients, 10 with generalized epilepsy and 19 with partial epilepsy. The relationships between epilepsy itself or antiepileptic drugs and P300 latency prolongation were analyzed.
RESULTS: P300 latency was prolonged in 9 (31%) of 29 patients with epilepsy. There were no significant relationships between etiology of epilepsy, type of seizures, or type of antiepileptic drug and P300 latency prolongation. The number or serum level of antiepileptic drugs and treatment duration were related to latency prolongation, but these relations were not significant.
CONCLUSIONS: The prolongation of P300 latency in event-related potentials is not significantly related to epilepsy itself and antiepileptic drugs. This findings suggests that P300 event-related potentials may not be a sensitive additional procedure to assess the cognitive status in patients with epilepsy.
[Supported by: This study was supported by a grant of Kosin University College of Medicine.]