Corpus Callosotomy for Drug-resistant Epilepsy Associated with Neuronal Migration Disorders
Abstract number :
2.468
Submission category :
9. Surgery / 9C. All Ages
Year :
2024
Submission ID :
526
Source :
www.aesnet.org
Presentation date :
12/8/2024 12:00:00 AM
Published date :
Authors :
Presenting Author: Kazushi Ukishiro, MD, PhD – Tohoku University Graduate School of Medicine
Shin-ichiro Osawa, MD, PhD – Tohoku University Graduate School of Medicine
Masaki Iwasaki, MD, PhD – National Center of Neurology and Psychiatry
Yosuke Kakisaka, MD, PhD – Tohoku University Graduate School of Medicine
Kazutaka Jin, MD, PhD – Tohoku University Graduate School of Medicine
Hidenori Endo, MD, PhD – Tohoku University
Nobukazu Nakasato, MD, PhD – Tohoku University Graduate School of Medicine
Rationale: Corpus callosotomy (CC) is a palliative surgical procedure suitable for certain patients with intractable seizures who are not candidates for focal resective surgery. Previous reports have indicated that patients without MRI abnormalities tend to have better prognoses. However, in patients with MRI abnormalities, there have been few reports discussing seizure outcomes in relation to specific disease types. This study aimed to investigate the seizure outcomes of CC in patients with drug-resistant epilepsy associated with neuronal migration disorders.
Methods: We reviewed nine patients (two men and five children) with lissencephaly (n=2), band heterotopia (n=1), and perisilvian polymicrogyria (n=6), who underwent complete CC (seven cases) or anterior three-fourths CC (two cases) for medically intractable drop attacks/infantile spasms. All patients had bilaterally synchronized EEG discharges preoperatively. The median age was 7 months and 8 years upon the onset of epilepsy and CC, respectively. The median duration was 64.5 months. We assessed the seizure outcomes of the overall and drop attacks after CC.
Results: For the overall seizure outcomes (N = 9), seizure reduction ( >50%) was achieved in three cases. For drop attacks (N = 7), seizure reduction ( >50%) was achieved in five cases. All cases had mild and transient complications.
Conclusions: CC is an excellent surgical option for treating drug-resistant epilepsy associated with neuronal migration disorders.
Funding: None.
Surgery