Deep Sleep Activation of Interictal Epileptiform Discharges Differs Between Temporal Lobe and Extratemporal Lobe Epilepsy Patients
Abstract number :
1.142
Submission category :
3. Neurophysiology / 3A. Video EEG Epilepsy-Monitoring
Year :
2021
Submission ID :
1826415
Source :
www.aesnet.org
Presentation date :
12/4/2021 12:00:00 PM
Published date :
Nov 22, 2021, 06:54 AM
Authors :
Franz Fürbass, PhD - AIT Austrian Institute of Technology GmbH; Johannes Koren, MD - Department of Neurology - Clinic Hietzing, Vienna, Austria; Manfred Hartmann - Center for Health & Bioresources - AIT Austrian Institute of Technology GmbH, Vienna, Austria; Ana Skupch - Center for Health & Bioresources - AIT Austrian Institute of Technology GmbH, Vienna, Austria; Laura Gschwandtner - Center for Health & Bioresources - AIT Austrian Institute of Technology GmbH, Vienna, Austria; Christoph Baumgartner - Head of Department, Department of Neurology, Clinic Hietzing, Vienna, Austria; Tilmann Kluge, PhD - AIT Austrian Institute of Technology GmbH, Vienna, Austria
Rationale: To investigate differences in timing of interictal epileptiform discharges (IED) in patients with temporal lobe epilepsy (TLE) compared to patients with extratemporal lobe epilepsy (eTLE) during three days of continuous video-EEG monitoring.
Methods: We retrospectively analyzed video-EEGs with a duration of 72 hours each recorded from 70 patients (42 TLE, 28 eTLE) to assess incident rates of IEDs. IEDs were automatically detected using an AI-based algorithm and then validated by visual inspection. Three feature values were calculated for each day and patient to capture activation patterns of IEDs. Circadian modulation feature was defined as IED rate between 9pm to 7am divided by the daily rate. Deep sleep IED activation was defined as the squared Pearsons’s correlation coefficient between normalized IED rate and the average percentage of delta band activity between 9pm to 7am. High values indicate that IEDs are activated during phases of deep sleep rather than other sleep stages. Seizure modulation considers a one-hour segment before and after all seizures (see [1] for details). A two-sided t-test for independent samples was used as test statistic with significance levels at p< 0.05.
Neurophysiology