Defining Cognitive Impairment in Temporal Lobe Epilepsy with IC-CoDE Phenotypes: A Comparison of Normative and Premorbid Approaches
Abstract number :
2.027
Submission category :
11. Behavior/Neuropsychology/Language / 11A. Adult
Year :
2025
Submission ID :
703
Source :
www.aesnet.org
Presentation date :
12/7/2025 12:00:00 AM
Published date :
Authors :
Presenting Author: Sofia Lesica, PhD – Cleveland Clinic
Kayela Arrotta, PhD – Cleveland Clinic
Yadi Li, MEd – Cleveland Clinic
Brittany Lapin, PhD, MPH – Cleveland Clinic
Lisa Ferguson, MA – Cleveland Clinic
Sara Swanson, PhD – Medical College of Wisconsin
Julie Janecek, PhD – Medical College of Wisconsin
Anny Reyes, PhD – Cleveland Clinic
Carrie McDonald, PhD – University of California, San Diego
Bruce Hermann, PhD – University of Wisconsin-Madison
Robyn Busch, PhD – Cleveland Clinic
Rationale: The International Classification of Cognitive Disorders in Epilepsy (IC-CoDE; McDonald et al., 2023) operationalizes cognitive phenotypes in epilepsy. Traditionally, cognitive impairment has been defined as < 1.5 SD below normative means to classify an individual into the appropriate cognitive phenotype. However, this approach is not entirely consistent with neuropsychological practice, where patients’ cognitive scores are not only compared against normative means but also against their own premorbid intellectual functioning (ipsative comparison). Our study aimed to evaluate an ipsative method to defining cognitive impairment to examine whether accounting for individuals' premorbid ability results in a different pattern of cognitive phenotypes.
Behavior