Delta Oscillation Coupled Propagating Fast Ripples Precede Epileptiform Discharges
Abstract number :
1.024
Submission category :
1. Basic Mechanisms / 1C. Electrophysiology/High frequency oscillations
Year :
2022
Submission ID :
2204049
Source :
www.aesnet.org
Presentation date :
12/3/2022 12:00:00 PM
Published date :
Nov 22, 2022, 05:23 AM
Authors :
Shennan Weiss, MD, PhD – SUNY Downstate; Laurent Sheybani, MD, PhD – Hôpitaux Universitaires de Genève; Nitish Seenarine, BA – SUNY Downstate; Itzhak Fried, MD, PhD – UCLA; Chengyuan Wu, MD, PhD – Thomas Jefferson University; Ashwini Sharan, MD – Thomas Jefferson University; Jerome Engel, MD, PhD – UCLA; Michael Sperling, MD – Thomas Jefferson University; Yuval Nir, PhD – Tel Aviv University; Richard Staba, PhD – UCLA
Rationale: Epilepsy can be considered a network disorder in which distinct and sometimes widespread brain regions coordinate their activity to generate seizures. Fast ripples (200-600 Hz) are associated with epileptogenic brain tissue and may play critical roles in the epileptic network.
Methods: We used macroelectrode stereo EEG recordings from a cohort of 46 patients and characterized fast ripples using topographical analysis and phasors. The location of each of the stereo EEG contacts was localized in normalized MNI coordinates. Fast ripple propagation was tested using the sign test. Fast ripple properties were compared using generlized linear mixed-effects models. Circular statistics utilized Bayesian projected normal regression model for circular data. Power spectral densities were compared using fitting oscillations and one over f (fooof).
Results: We found that propagating fast ripples exhibited a distinct frequency and larger power (p< 1e-4) and were strongly phase coupled to the peak of delta oscillation DOWN states during non-REM sleep (p< 1e-10). Fast ripple propagation in the seizure onset zone often was followed by an epileptiform spike (p< 0.05).
Basic Mechanisms