Differences in Slow Wave Activity Between Focal Seizures with versus Without Impaired Consciousness and Sleep: A High-density EEG Study
Abstract number :
3.167
Submission category :
3. Neurophysiology / 3C. Other Clinical EEG
Year :
2022
Submission ID :
2204672
Source :
www.aesnet.org
Presentation date :
12/5/2022 12:00:00 PM
Published date :
Nov 22, 2022, 05:26 AM
Authors :
Atakan Selte, MD – University of Wisconsin-Madison; Kyle Shoger, BS – Honorary Associate, Department of Neurology, University of Wisconsin-Madison; Brinda Sevak, MSc – Research Specialist, Department of Neurology, University of Wisconsin-Madison; Atakan Selte, MD – Research Specialist, Department of Neurology, University of Wisconsin-Madison; Mariel Kalkach Aparicio, MD – Research Specialist, University of Wisconsin-Madison, Department of Neurology; Ruben Verhagen, MA, MSc – PhD Candidate, Department of Humanities, Vrije Universiteit Amsterdam; Elsa Juan, PhD – Faculty of Social and Behavioral Sciences – University of Amsterdam; Graham Findlay, BS – PhD student, Department of Psychiatry, University of Wisconsin-Madison; Tom Bugnon, BS – Research Analyst, Department of Psychiatry, University of Wisconsin-Madison; Armand Mensen, PhD – Postdoctoral Fellow, Netherlands Institute of Neuroscience; Rama Maganti, MD – Professor, Department of Neurology, University of Wisconsin-Madison; Giulio Tononi, MD, PhD – Professor, Department of Psychiatry, University of Wisconsin-Madison; Aaron Struck, MD – Assistant Professor, Department of Neurology, University of Wisconsin-Madison; Melanie Boly, MD, PhD – Assistant Professor, Department of Neurology, University of Wisconsin-Madison
Rationale: Evidence from intracranial EEG (iEEG) studies suggests that impaired consciousness during focal seizures is linked to increases in slow-wave activity (SWA). We used high-density EEG (HDEEG) to investigate differences in SWA and other frequency bands between focal seizures with preserved vs impaired consciousness (FA vs FIA), wake and non-rapid eye movement (NREM) stages 2 and 3 of sleep._x000D_
Methods: HDEEG recordings were performed on patients with focal epilepsy at the University of Wisconsin-Madison Epilepsy Monitoring Unit. Our population was comprised of patients with FIA (n = 19 from 7 patients, mean age 43 ± SD 11, 4 females; focus location in bilateral temporal: n =2; R temporal: n = 4; and R occipital: n = 1) and others with FA (n = 7 from 3 patients, mean age 38 ± SD 9, 1 female; focus locations in R temporal: n = 2; and R occipital: n = 1). HDEEG data was filtered between 1-25 Hz, with visual rejection of epochs and channels with artifact. Seizure data was concatenated with data pertaining to sleep N2 and N3 stages (yielding 18/19 FIA and 5/7 FA) and wake (W) states before Independent Component Analysis (ICA). Topographies of EEG power in the SWA (Delta, 1-4 Hz), Theta (4-8 Hz) and Sigma (12-15 Hz) bands and Delta/Beta (DBr, 15-25 Hz) ratio were compared across seizure types and states (both for absolute and spatially Z-scored values). Random effects analysis used Statistical Parametric Mapping software (threshold set at p< 0.05 with correction for multiple comparisons at voxel or cluster levels)._x000D_
Neurophysiology