Differential Phenotyping of Neuropsychological Profile Among Different Temporal Lobe Epilepsy
Abstract number :
2.018
Submission category :
11. Behavior/Neuropsychology/Language / 11A. Adult
Year :
2025
Submission ID :
192
Source :
www.aesnet.org
Presentation date :
12/7/2025 12:00:00 AM
Published date :
Authors :
Presenting Author: Mingqian Li, BS – University of Pittsburgh Medical Center
Erafat Rehim, MD – University of Pittsburgh Medical Center
Tipakorn Tumnark, MD – University of Pittsburgh Medical Center
Danielle Carns, PsyD – University of Pittsburgh Medical Center
Natalie Sherry, PsyD – University of Pittsburgh Medical Center
Jorge González-Martínez, MD,PhD – University of Pittsburgh Medical School
Thandar Aung, MD,MS – University of Pittsburgh Medical School
Luke Henry, PhD – University of Pittsburgh Medical Center
Rationale: Temporal lobe epilepsy (TLE) is the most common focal epilepsy in adults and is frequently associated with decline in memory, language, executive function, and visuospatial skills [1,2,3]. This study aimed to profile neuropsychological performance across mesial, temporal pole, and basal temporal TLE to clarify subtype-specific cognitive phenotypes.
Methods: This retrospective study, conducted under IRB approval at the University of Pittsburgh Medical Center, included 19 adults with drug-resistant TLE who underwent stereo-EEG (SEEG) monitoring and subsequent temporal lobe resection, with at least two years of postoperative outcome data. Patients were classified as having mesial, temporal pole, or basal temporal seizure onset. Standardized T-scores were obtained across the following domains: Language, Executive Function, Attention, Processing Speed, Visuospatial Functions, Verbal Memory, and Visuospatial Memory. Scores were grouped into seven bands. Proportions were visualized, and Kruskal–Wallis tests were used to compare continuous scores, Likelihood ratio χ² tests assessed differences in categorical distributions (high ≥ 57, average = 43–56, low <
Behavior