Disordered Neuronal Excitability in anti-lgi1 Autoimmune Encephalitis
Abstract number :
2.572
Submission category :
5. Neuro Imaging / 5B. Functional Imaging
Year :
2024
Submission ID :
1383
Source :
www.aesnet.org
Presentation date :
12/8/2024 12:00:00 AM
Published date :
Authors :
Presenting Author: Yudi Zhang, MD – Beijing Tiantan Hospital, Capital Medical University; The Second Hospital of Hebei Medical University
Ruijuan Lv, MD, PhD – Beijing Tiantan Hospital, Capital Medical University; China National Clinical Research Center for Neurological Diseases
Qun Wang, MD – Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China
Rationale: In patients with anti-leucine-rich glioma-inactivated 1 (LGI1) autoimmune encephalitis, the antibodies bind to the LGI1 protein, which lead to reversible damage of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid-type glutamate receptors (AMPARs) and abnormal neuronal excitability.
Methods: We retrospectively compared the difference of whole brain amplitude of low frequency fluctuation (ALFF) between 19 patients with anti-LGI1 autoimmune encephalitis and 19 healthy controls.
Results: In patients with anti-LGI1 autoimmune encephalitis, the ALFF increased in bilateral frontal lobe, parietal lobe, thalamus, left putamen, temporal lobe, hippocampus, occipital lobe, cerebellum, right caudate nucleus and brain stem; decreased in bilateral frontal lobe, right parietal lobe, temporal lobe, and occipital lobe. (threshold-free cluster enhancement permutation 5000 times, P < 0.001, cluster > 50 voxels)
Conclusions: In patients with anti-LGI1 autoimmune encephalitis, the neuronal excitability is widely disordered in frontal lobe, parietal lobe, temporal lobe, occipital lobe, thalamus, hippocampus, basal ganglia, cerebellum, and brain stem.
Funding: This study was supported by the National Key R&D Program of China grant [2022YFC2503800], National Natural Science Foundation of China [82371449], the Beijing Natural Science Foundation [7232045, Z200024 and L222033], Capital Health Research and Development of Special grants [2020-1-2013], and the health commission of Hebei Province [20230635].
Neuro Imaging