Authors :
Presenting Author: Xiaowei Xu, MD – The Seventh Affiliated Hospital of Sun Yat-sen Univerisity; Second Affiliated Hospital, Zhejiang University School of Medicine, China
Hongyi Ye, MD – Second Affiliated Hospital, Zhejiang University School of Medicine
Lingqi Ye, MD – Second Affiliated Hospital, Zhejiang University School of Medicine
Lingli Hu, MD – Second Affiliated Hospital, Zhejiang University School of Medicine
Zhe Zheng, MD – Second Affiliated Hospital, Zhejiang University School of Medicine
Zhongjin Wang, MD – Second Affiliated Hospital, Zhejiang University School of Medicine
Junming Zhu, MD – Second Affiliated Hospital, Zhejiang University School of Medicine
Liemin Zhou, MD – The seventh affiliated hospital, Sun Yay-sen University
Shuang Wang, MD – Second Affiliated Hospital, Zhejiang University School of Medicine
Rationale:
The centromedian thalamic nucleus (CM) is critical for sleep-wake regulation and a target for deep brain stimulation in drug-resistant epilepsy.This study characterized intrinsic CM EEG dynamics and interictal epileptiform discharges (IEDs) via stereoelectroencephalography (SEEG) .
Methods:
SEEG from CM, ventroposterior (VP), and ventrolateral (VL) nuclei was analyzed in 34 drug-resistant focal epilepsy patients and one non-epileptic control. Sleep staging used scalp EEG, electrooculography, and chin EMG (AASM criteria). Quantitative spectral power analysis covered wakefulness, NREM (N2–N3), and REM sleep. The onset latency between thalamic SEEG changes and scalp EEG arousal was quantified for one randomly chosen spontaneous arousal. Thalamic IEDs were visually identified using a strict criterion: the morphology meets the standard of epileptiform discharge on scalp EEG, and time-locked to epileptiform discharges in the seizure onset zone (SOZ) or the exclusively irritative zone (EIZ) (≤150 ms gap).
Results:
The SEEG of CM, VP, and VL nuclei exhibited consistent sleep-wake-dependent changes.
During wakefulness, thalamic SEEG was characterized by low-amplitude (< 20