Abstracts

Pediatric patients with epilepsy and their caretakers must contend not only with the challenge of uncontrolled seizures, but also with the impact of this chronic condition on their quality of life and daily activities. Breakthrough seizures may occur at any time; as a result, it is important that parents be able to manage their child[rsquo]s seizure emergencies. The underlying anxiety and stress about seizure emergencies impact the entire family and may unnecessarily limit a child[rsquo]s activities. These considerations underscore the value and importance of having a portable rescue medication available. Diazepam rectal gel is the only portable rescue medication approved by the Food and Drug Administration for the at-home treatment of breakthrough seizures. The purpose of this study is to investigate the impact of diazepam rectal gel use on the quality of life of patients with epilepsy and their caregivers. A survey including quality of life issues pertaining to diazepam rectal gel use was given to consecutively treated children with epilepsy who are currently using the drug and to their caregivers. Survey questions assessed patient medical history, experience with diazepam rectal gel, and consequent changes in lifestyle, if any. Demographic data, including duration of epilepsy and developmental level, seizure type, and number/types of concomitant medications were evaluated to provide a comprehensive background of the range of patients using diazepam rectal gel. Patient history included seizure types for which diazepam rectal gel is used, length of time patient has been using the drug, and number of times used. Questions about patient and caregiver experience with diazepam rectal gel assessed its effect on the following parameters: duration of lasting effect following use, change in duration of seizures, and number of visits to the emergency department. The level of caregiver education was also queried. To evaluate whether diazepam rectal gel affects patient and caregiver involvement in daily activities, the questionnaire sought information about the following areas: travel outside the home (eg, shopping, vacations), time lost from work or school, perceived ability to participate in activities typical of the patient[rsquo]s age group, perceived sense of control over one[rsquo]s life, and incorporation of diazepam rectal gel as part of an emergency seizure treatment plan at school. Preliminary results indicate that, overall, patients with epilepsy and their caregivers reported a high level of satisfaction with diazepam rectal gel and improvement in aspects of quality of life. Diazepam rectal gel is associated with improved quality of life for patients with epilepsy and their caregivers. This survey will provide valuable data in further elucidating the ways in which diazepam rectal gel assists patients and their families in maintaining usual activities and living a more [ldquo]normal[rdquo] life. (Supported by Xcel Pharmaceuticals)