Effectiveness of a Live-online Mindfulness Intervention, Making Mindfulness Matter, for Improving Health-related Quality of Life of Children with Epilepsy: A Pilot Randomized Trial
Abstract number :
1.149
Submission category :
16. Epidemiology
Year :
2024
Submission ID :
1281
Source :
www.aesnet.org
Presentation date :
12/7/2024 12:00:00 AM
Published date :
Authors :
Presenting Author: Karina Tassiopoulos, BS, PhD Candidate – Western University
Karen Bax, PhD, C. Psych – Western University
Klajdi Puka, PhD – Western University
Andrea Andrade, MD – Children's Health Research Institute
Margo Devries-Rizzo, NP-Paeds – London Health Sciences Centre
Michelle Franklin, BA – Merrymount Family Support & Crisis Centre
Hema Gangam, MD – Western University
Simon Levin, MD – Children's Health Research Institute
Maryam Nouri, MD – Children's Health Research Institute
Asuri Prasad, MBBS, MD – Children's Health Research Institute
Mary Secco, MHIS – Epilepsy Southwestern Ontario
Edigio Spinelli, MD – Western University
Guangyong Zou, PhD – Western University
Evelyn Vingilis, PhD – Western University
Kathy Speechley, PhD – Western University
Rationale: Epilepsy detrimentally affects health-related quality of life (HRQOL), with family environment being a key determinant of HRQOL in children with epilepsy (CWE). We evaluated the feasibility of a mindfulness-based program, Making Mindfulness Matter (M3©), to improve HRQOL in CWE and their parents. This analysis examines the treatment effect of M3© on HRQOL in CWE.
Methods: We conducted a parallel 1:1 randomized controlled trial (n = 73: intervention = 36, control = 37) comparing the 8-week intervention to waitlist control in children aged 4-10 with epilepsy in Ontario. Non-clinician staff from a local epilepsy agency delivered M3© online, synchronously to small groups of parent-child dyads. HRQOL in CWE was measured using the parent-reported 55-item Quality of Life in Childhood Epilepsy Questionnaire (QOLCE-55). Intention-to-treat analysis using linear mixed models compared mean QOLCE-55 scores between arms 1-week post-M3©, adjusting for baseline scores and accounting for clustering of dyads who received M3© together. We then evaluated changes in mean QOLCE-55 scores in the intervention arm from (1) baseline to 1-week post-M3© and (2) baseline to 10-weeks post-M3©.
Results: M3© was associated with improved HRQOL; participants who received M3© showed a 7-point increase in mean QOLCE-55 scores relative to controls (95% CI: 2.09-11.68). In the intervention arm, mean scores improved by 5 points at 1-week post-M3© (95% CI: 1.26-9.31) and 4 points at 10-weeks post-M3© (95% CI: -0.07-8.41).
Conclusions: Findings provide preliminary evidence for M3©’s effectiveness in improving short-term HRQOL in CWE, suggesting the potential value of low-cost, community-based interventions to support quality of life for families and children living with epilepsy. These results, along with feasibility results, will be used to prepare a larger multi-centered trial.
Funding: Project Grant from the Canadian Institutes of Health Research (PJT 159504).
Epidemiology