Abstracts

Rationale: Drug-resistant epilepsy is defined  as a failure of adequate and sustained  seizure control following the testigo of two  appropriately selected, well tolerated and dosed antiepileptic drug(1). It is estimated that 30 to 36% of patients with epilepsy continue to have seizures despite adequate pharmacological therapy, which causes a negatively impact in life quality (2).Vagus nerve stimulation (VNS) Therapy has been proved to reduce seizures in pediatric patients by more than 50%(3) Methods: The response to 12 months of VNS therapy was evaluated in 16 patients under 18 years of age with diagnosis of DRE, the reduction rate in the number of seizures, duration, magneto response, side effects and hospitalization pre and post-surgery were quantified.  Results: The mean age was 12.6 years, the rate of seizure reduction was 80.5%, two patients were seizure free and one had 17% reduction in the total number of seizures. Hospitalizations were reduce by 85%, 30% had temporaly side effects and 62% were able to stop or reduce seizure duration with the magneto.  Conclusions: VNS therapy is a safe and effective in the management of patients with DRE and it improves quality of life. It requires health administrators as a therapy of choice in order to be used in the early stages of the patient with epilepsy.  Funding: 1.kwan P, et al. Epilepsy 2009, Doi:1011111/j.1528-1167.20092.Brodie MJ, Kwan P. Neurology. 2002, 58(suppl 5)S2-S8.3.George L. Morros II Neurology 2013, 81:1453-14594.Malow BA. et al. Neurology. 2001, 57:879-884.