Electroencephalographic Features in Pediatric Patients with Moyamoya Disease
Abstract number :
1.31
Submission category :
4. Clinical Epilepsy / 4B. Clinical Diagnosis
Year :
2024
Submission ID :
1334
Source :
www.aesnet.org
Presentation date :
12/7/2024 12:00:00 AM
Published date :
Authors :
Presenting Author: Tuanfeng Yang, – Peking University International Hospital
Qing Xia, MB – Peking University International Hospital
Ran Duan, MD – Peking University International Hospital
Rong Wang, MD – Beijing Tiantan Hospital
Yuanli Zhao, MD – Peking Union Medical College Hospital
Xu Wang, MD – Beijing Children's Hospital
Xianzeng Liu, MD – Peking University International Hospital; Clinical Research Institute, Institute of Advanced Clinical Medicine, Peking University
Rationale: Moyamoya disease (MMD) is a chronic, occlusive cerebrovascular disease with an uncertain etiology characterized by bilateral steno-occlusive changes at the terminal portion of the internal carotid artery and an abnormal vascular network at the base of the brain. MMD is a relatively important and common disease, especially in East Asian. There are few reports about electroencephalography (EEG) in pediatric patients with MMD till now. This study is aimed to analyze the electroencephalographic features of MMD in pediatric patients in China preliminarily.
Methods: Pediatric patients with MMD who were hospitalized in Peking University International Hospital from January 2016 to December 2021 were collected. Clinical and EEG findings were analyzed retrospectively.
Results: A total of 214 pediatric patients with MMD were involved, and 30 (14.0%) cases had a history of seizure or epilepsy. 160 (74.8%) patients presented with transient neurological symptoms, including transient ischemic attack, seizure, headache, and syncope. A subset of 32 patients with complete EEG data was identified. Common indications for EEG in patients with MMD included limb shaking, unilateral weakness, or generalized convulsion. Abnormal EEG was seen in 31 (96.9%) cases, with the most common findings being focal slowing 25 (80.6%), followed by epileptiform discharge 20 (64.5%), and diffuse slowing 19 (61.3%). "Re-build up" phenomenon on EEG was observed in one patient.
Conclusions: EEG has not attracted much attention in clinical practice in MMD. Seizure and abnormal background activity or epileptiform discharge on EEG were common in pediatric patients with MMD. EEG may play a role in differential diagnosis among the transient neurological events in MMD such as transient ischemic attack and seizure.
Funding: None
Clinical Epilepsy