Authors :
Juhyun Kong, MD – Pusan National University School of Medicine
SooYoung Lyu, MD – Pusan National University School of Medicine
Sang Ook Nam, MD – Pusan National University School of Medicine
Presenting Author: Yun-Jin Lee, MD – Pusan National University School of Medicine
Rationale:
Seizures can be described in inflammatory bowel disease (IBD) as the extraintestinal manifestations. Information in pediatrics has been based rarely on individual case reports. This study is aimed to investigate the prevalence and clinical characteristics of seizures and electroencephalographic (EEG) abnormalities in children with IBD. Methods:
We conducted a retrospective study based on a computer-guided medical search, of children with Crohn’s disease (CD) or ulcerative colitis (UC) diagnosed from 2010 through 2023. Children with IBD including CD or UC, who developed seizures were consulted by a pediatric neurologist.
Results:
Based on clinical features and neurologic evaluation, eight (1.9%; boy/girl = 4//4) patients of the 415 children in our IBD clinic were diagnosed with pediatric epilepsy, a higher prevalence than would be expected from population prevalence of the disease. Their ages ranged from 7 to 17 years. Most of the patients developed their first unprovoked seizure coincidental or after gastrointestinal symptoms appeared. There was a slight predominance in UC (UC/CD = 6/2), and association was seen between epilepsy and UC (p< 0.05) rather than CD. Three children (3/8, 37.5%) have showed uncontrolled focal-onset seizures by ketogenic diet and vagus nerve stimulation as well as several anti-seizure medications, and all three were women.