Epilepsy Diagnosis and Management in Children with Autism Spectrum Disorders: A Single Center Retrospective Cohort Study
Abstract number :
2.09
Submission category :
4. Clinical Epilepsy / 4A. Classification and Syndromes
Year :
2022
Submission ID :
2204372
Source :
www.aesnet.org
Presentation date :
12/4/2022 12:00:00 PM
Published date :
Nov 22, 2022, 05:24 AM
Authors :
Karen Lob, BS – Brown University; Duyu A. Nie, MD, PhD – Warren Alpert Medical School of Brown University; Tao Hou, PhD – Nutrition – Harvard T.H. Chan School of Public Health; Nouran Ibrahim, BA – Warren Alpert Medical School of Brown University; Tzu-Chun Chu, MPH – Epidemiology and Biostatistics – University of Georgia; Luca Bartolini, MD – Assitant Professor, Pediatrics, Neurology, and Neurosurgery, Warren Alpert Medical School of Brown University
This abstract has been invited to present during the Clinical Research platform session
Rationale: There is a lack of population-based EEG and clinical assessment of epilepsy associated with autism spectrum disorders. Therefore, this study aims to investigate the electroclinical, radiological, genetic aspects of their epilepsies, and treatment response in children with autism, which could inform clinical practice.
Methods: Retrospective chart review was conducted on 298 patients – 150 with both autism and_x000D_
epilepsy and 148 demographically matched patients with epilepsy only – who were seen for seizure management between April 2015 and March 2020. Clinical variables obtained included: seizure semiology, age of epilepsy onset, anti-seizure medications (ASMs), nonpharmacologic treatments for epilepsy, EEG and MRI findings and genetic testing results. Chi-square or Fisher’s exact test were used to compare the frequency of clinical features between the two cohorts with p < 0.05 considered statistically significant.
Clinical Epilepsy