Authors :
Presenting Author: Cemal Karakas, MD – Children's National Hospital
M. Scott Perry, MD – Cook Children’s Physician Network
Avery Caraway, BS, MS – Cook Children's
Edward Novotny, MD – Seattle Children's Hospital
Dewi Depositario-Cabacar, MD – Children's National
William Gaillard, MD – Children's National Hospital
Chima Oluigbo, MD – Children's National Hospital, George Washington University
Allyson Alexander, MD, PhD – Children’s Hospital of Colorado
Krista Eschbach, MD – Children Hospital Colorado
Priyamvada Tatachar, MBBS, MD – Ann & Robert H. Lurie Children’s Hospital of Chicago
Pilar Pichon, MD – Children's Hospital of Orange County
Daniel Shrey, MD – Children’s Hospital of Orange County
Jeffrey Bolton, MD – Boston Childrens Hospital
Nancy McNamara, MD – University of Michigan
Jason Coryell, MD – Oregon Health Sciences University
Adam Ostendorf, MD – Division of Neurology, Department of Pediatrics, Nationwide Children’s Hospital and The Ohio State University College of Medicine, Columbus, OH
Michael Ciliberto, MD – University of Iowa
Shilpa Reddy, MD – Vanderbilt University
Abhinaya Ganesh, MD – Vanderbilt University
Andrew Knox, MD – University of Wisconsin-Madison
Rani Singh, MD – Atrium Health
Ernesto Gonzalez-Giraldo, MD – University of California at San Francisco
Kurtis Auguste, MD – University of California at San Francisco
Danilo Bernardo, MD – University of California at San Francisco
Lily C. Wong-Kisiel, MD – Mayo Clinic, Rochester, MN, USA.
Ahmad Marashly, MD – John Hopkins
Kristen Arredondo, MD – University of Texas at Austin, Dell Medical School
Samir Karia, MD – University of Louisville
Taylor Abel, MD – Children's Hospital of Pittsburgh, UPMC
Jenny Lin, MD – Children’s Healthcare of Atlanta
Debopam Samanta, MD – University of Arkansas
Pradeep Javarayee, MD MBA – The Medical College of Wisconsin, Milwaukee
Zachary Grinspan, MD, MS – Cornell Weill Medicine
Srishti Nangia, MD – Cornell Medical School
Dallas Armstrong, MD – UT Southwestern
Fernando Galan, MD – Nemours Children’s Health
Derryl Miller, MD – Indiana University School of Medicine
Nathan Cohen, MD – Children's National Hospital
Rationale:
Focal cortical dysplasia (FCD) is the most common cause of surgically treatable, drug-resistant epilepsy (DRE) in children. Surgical teams may use one-stage (without extraoperative intracranial monitoring) or two-stage (intracranial monitoring followed by further surgery) approaches; however, the factors associated with this decision is not well understood. This study aims to compare patient characteristics and outcomes of children with FCD-DRE between one-stage and two-stage surgeries.
Methods:
We performed a retrospective analysis of children < 18-year-old with FCD-DRE from the multicenter, prospective Pediatric Epilepsy Research Consortium (PERC) Surgery Database. Variables analyzed included demographics, seizure characteristics, imaging results, and surgical details between one- and two-stage procedures. Outcomes were compared between the two groups for patients with at least 6 months follow-up. Stepwise logistic regression model was used to identify predictors of two-stage surgery.