Authors :
Presenting Author: Claude Steriade, MD – Department of Neurology, NYU Langone Medical Center, New York City
Scott Thomas, PhD – NYU
Fangxi Xu, MSc – NYU
Gabriella Foca, BA – NYU Grossman School of Medicine
Jacqueline French, MD – Department of Neurology and Comprehensive Epilepsy Center, New York University Grossman School of Medicine, NYU Langone Health
Orrin Devinsky, MD – NYU Comprehensive Epilepsy Center, NYU Langone Medical Center
Deepak Saxena, PhD – NYU
Rationale:
Gut microbiome manipulation is a potential epilepsy therapy. The gut microbiome of people with epilepsy differs from healthy people, and studies suggest a role for gut dysbiosis in drug resistant epilepsy. We examined the relationship between gut microbiota and seizure control in idiopathic generalized epilepsy (IGE) subjects enrolled in the Human Epilepsy Project 3 (HEP3).
Methods:
HEP3 subjects were >13 years at enrollment and >6 years at seizure onset. HEP3 enrolled three cohorts: 1) newly diagnosed (< 1