HEART RATE DYNAMICS IN REFRACTORY AND WELL CONTROLLED TEMPORAL LOBE EPILEPSY [ndash] A FOUR-YEAR FOLLOW-UP STUDY
Abstract number :
3.098
Submission category :
Year :
2005
Submission ID :
5904
Source :
www.aesnet.org
Presentation date :
12/3/2005 12:00:00 AM
Published date :
Dec 2, 2005, 06:00 AM
Authors :
1Eija Ronkainen, 1Juha T. Korpelainen, 2Heikki V. Huikuri, 1Vilho V. Myllylä, and 1Jouko I.T. Isojärvi
To prospectively evaluate changes in interictal heart rate (HR) variability in patients with temporal lobe epilepsy (TLE) after 4 years follow-up. A 24-hour ECG recording was obtained at baseline and four years after first recording in 18 patients with refractory TLE, 18 patients with well controlled TLE, and once in 36 healthy age- and sex-matched control subjects. Time and frequency domain measures, along with fractal and complexity measures of HR variability, were analysed from the ECG recordings. At baseline most of the measures showed decreased HR variability in the TLE patients compared to control subjects. After four years follow-up, most of the HR variability measures were further decreased in patients with TLE, and the RR interval (p = 0.015), the Poincaré component SD[sub]2[/sub] (p [lt] 0.002), and ApEn (p = 0.000) value decreases from the baseline were statistically significant. TLE was associated with reduced HR variability at the baseline of the study. Further decrease in HR variability in patients with TLE was observed after four-year follow-up