HIPPOCAMPUS ATROPHY VS. HYPOMETABOLISM OF LATERAL TEMPORAL CORTEX IN MESIAL TEMPORAL LOBE EPILEPSY
Abstract number :
3.175
Submission category :
Year :
2002
Submission ID :
341
Source :
www.aesnet.org
Presentation date :
12/7/2002 12:00:00 AM
Published date :
Dec 1, 2002, 06:00 AM
Authors :
Won Chul Shin, Eun Kyung Lee, Won Tae Yoon, Su Jung Choi, Dae Won Seo, Seung Chyul Hong, Sang Eun Kim, Dae Soo Jung, Seung Bong Hong. Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; Neurosurgery, Samsung Medica
RATIONALE: The hippocampal sclerosis is frequently accompanied by PET hypometabolism (PET-Hypo) of lateral temporal cortex. But its mechanism remains unclear. We investigated whether the PET-Hypo of lateral temporal cortex is related to the atrophy and PET-Hypo of hippocampus.
METHODS: Fifteen patients with mesial temporal lobe epilepsy (TLE) underwent 18F-FDG PET and volumetric MRI with 1.6 mm thickness. Hippocampus was divided into head, body and tail while lateral temporal cortex was divided into anterior, mid- and posterior 1/3. Hippocampal volume and PET metabolism of each region were measured by a semi-automated method and PET-MRI co-registration with adjusting PET ROI from SPGR MRI. Asymmetry indices of hippocampal volume (Vol-asym) and PET metabolism (PET-asym) in each region were calculated by the formula of the value of epileptic side / the value of non-epileptic side. The correlation coefficient was tested among Vol-asym of regional hippocampus, PET-asym of regional hippocampus and lateral temporal cortex.
RESULTS: There were nine left TLE and six right TLE. There were significant correlations between Vol-asym and PET-asym in head (r=0.705), body (r=0.56) and tail (r=0.59) of the hippocampus (p[lt]0.05). The PET-asym of anterior 1/3 of lateral temporal cortex was significantly correlated with Vol-asym of hippocampal head (r=0.662, p=0.01) and had a weak correlation with PET-asym of hippocampal head (r=0.424, p=0.065). But there was no correlation of body and tail of hippocampus with mid- and posterior 1/3 of lateral temporal cortex.
CONCLUSIONS: The degree of hippocampal atrophy was correlated with not only PET-Hypo of hippocampus but also PET-Hypo of anterior lateral temporal cortex. This result suggests that PET-Hypo of lateral temporal cortex is partly due to decreased fiber connections from atrophic hippocampus.
[Supported by: a grant (No. HMP-01-PJ8-PG3-21301-0009) of the Good Health R&D Project, Ministry of Health & Welfare, Republic of Korea.]