Impact of Responsive Neurostimulation on Health-Related Quality of Life in Pediatric and Young Adult Patients with Drug-Resistant Epilepsy
Abstract number :
1.087
Submission category :
11. Behavior/Neuropsychology/Language / 11B. Pediatrics
Year :
2025
Submission ID :
544
Source :
www.aesnet.org
Presentation date :
12/6/2025 12:00:00 AM
Published date :
Authors :
Presenting Author: Reilly Philliben, DO – University of Utah School of Medicine
Audie Espinoza, MD – University of Utah School of Medicine
Deirdre Caplin, PhD – University of Utah School of Medicine
Shanna Swartwood, MD – University of Utah School of Medicine
Rationale: Drug-resistant epilepsy (DRE) is linked to a higher risk of reduced health-related quality of life (HRQOL). is population remains underexplored. This study evaluates HRQOL changes after RNS implantation in pediatric and young-adult patients with DRE.
Methods: A retrospective review was conducted on pediatric and young adult patients with DRE who underwent RNS implantation at Primary Children’s Hospital in Salt Lake City, UT. Patients and caregivers who completed the PedsQL Epilepsy Module (PedsQL-EM) both pre‑implantation and at 24 months post‑implantation were included. a small, exploratory sample, we summarized HRQOL change with Wilcoxon effect sizes (r) and omitted p‑values to avoid overstating under‑powered results. Minimal clinically important difference achievement was assessed using published domain‑specific thresholds; results are presented as proportions of patients meeting MCID in each domain. Patient–caregiver concordance was described with Spearman correlation coefficients (ρ), while discordance was expressed as effect sizes. To explore the relationship between seizure reduction and HRQOL, change scores were compared descriptively between RNS responders (≥ 50% seizure reduction) and non‑responders (< 50% reduction) using rank‑based effect size
Behavior