Interneuronopathies Diversity in the phenotypes of genetic mutations that alter forebrain GABAergic interneuron ontogeny
Abstract number :
IW.09
Submission category :
Year :
2010
Submission ID :
12987
Source :
www.aesnet.org
Presentation date :
12/3/2010 12:00:00 AM
Published date :
Dec 2, 2010, 06:00 AM
Authors :
Elizabeth Powell
Summary: Disturbances in genes that control GABAergic neuronal ontogeny share a common outcome of seizure susceptibility. However, the overall anatomical characterizations are diverse, with some mutations leading to severe malformations, whereas losses of other genes have brains that appear to be largely normal. The affected subpopulations are biochemically unique. The reported onset and types of seizure behaviors varies with genetic manipulation and interneuron repertoire. This workshop will review the common developmental origins of the forebrain interneurons and compare anatomical and physiological outcomes with genetic disruptions. Where possible, strategies for correcting or repairing the deficits will be discussed.