Abstracts

Rationale: Levetiracetam had been used in adjuvanctive Therapy. Levetiracetam is also used in monotherapy in other coutries, so we also studied the Levetiracetam monotherapyMethods: We retrospectively studied the type of epielpsy, EEG, Brain MRI, dose of drug. We studied 101 children who visited our hospital because of seizure since August 2007 to July 2009. Results: The Age is from 1 month to 20 years 1) The mean age of taking Levetiacetam initialy is 11 4 years( from 3 years to 21 years). 2) The types of epilepsy were Partial in 57.4% and generalized in 42.6%. 3) The mean dose started initialy is 6 4mg/kg/day (from 2mg/kg/day to 30mg/kg/day). The mean final dose is 30 8mg/kg/day (from 6mg/kg/day to 60mg/kg/day). 4)The mean duration of therapy is 21 11months, and the duration of therapy ranged from 1 to 38months. 5) 85.1% of patients became seizure free, 88.1% decresed at least 50% reduction in seizure during 12 months. 6) The side effects is that behavioral change is 8, asthenia is 2, cognitive change is 1, rash is 2, headache is 5, inadequate seizure control is 2, increased seizure is 5. 7)Levetiracetam was discontinued because inadequate seizure control is 2, increased seizure is 5 and side effects is 2. Conclusions: We studied efficacy and tolerability of monotherapy of Levetiracetam. Levetiracetam is effective and tolerable in monotherapy of epilepsy.