Abstracts

Multi-centre Normative Brain Mapping of Intracranial EEG Lifespan Patterns in the Human Brain

Abstract number : 3.3
Submission category : 3. Neurophysiology / 3G. Computational Analysis & Modeling of EEG
Year : 2024
Submission ID : 209
Source : www.aesnet.org
Presentation date : 12/9/2024 12:00:00 AM
Published date :

Authors :
Presenting Author: Heather Woodhouse, MSc – Newcastle University

Gerard Hall, PhD – Newcastle University
Callum Simpson, BSc – Newcastle University
Csaba Kozma, BSc – Newcastle University
Frances Turner, PhD – Newcastle University
Gabrielle M. Schroeder, PhD – Newcastle University
Beate Diehl, MD – University College London
John Duncan, MD – University College London
Jiajie Mo, MD, PhD – Beijing Tiantan Hospital
Kai Zhang, MD – Beijing Tiantan Hospital
Aswin Chari, PhD – Great Ormond Street Hospital for Children
Martin Tisdall, MD, PhD – Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
Friederike Moeller, PhD – Great Ormond Street Hospital for Children
Chris Petkov, PhD – University of Iowa Hospitals and Clinic
Matthew A. Howard, MD – University of Iowa Hospitals and Clinic
George Ibrahim, MD, PhD – The Hospital for Sick Children
Elizabeth Donner, MD, FRCPC – Hospital for Sick Children
Nebras Warsi, MD, CM – The Hospital for Sick Children
Raheel Ahmed, MD, PhD – University of Wisconsin-Madison
Peter Taylor, PhD – Newcastle University
Yujiang Wang, PhD – Newcastle University

Rationale: Understanding healthy human brain function is crucial to identify and map pathological tissue within it. Whilst previous studies have mapped intracranial EEG (icEEG) from non-epileptogenic brain regions, these maps do not consider the effects of age and sex. Further, most existing work on icEEG has often suffered from a small sample size due to this modality’s invasive nature. Here, we substantially increase the subject sample size compared to existing literature, to create a multi-centre, normative map of brain activity which additionally considers the effects of age, sex and recording site.

Methods: Using interictal icEEG recordings from n = 513 subjects originating from 15 centres, we constructed a normative map of non-pathological brain activity by regressing age and sex on relative band power in five frequency bands, whilst accounting for the site effect.

Results: Recording site significantly impacted normative icEEG maps in all frequency bands, and age was a more influential predictor of band power than sex. The age effect varied by frequency band, but no spatial patterns were observed at the region-specific level. Certainty about regression coefficients was also frequency band specific and moderately impacted by sample size.

Conclusions:
The concept of a normative map is well-established in neuroscience research and particularly relevant to the icEEG modality, which does not allow healthy control baselines. Our key results regarding the site and age effect guide future work utilising normative maps in icEEG.




Funding:

  • UKRI Future Leaders Fellowships (MR/T04294X/1, MR/V026569/1)

  • Engineering and Physical Sciences Research Council (EP/L015358/1)

  • NIHR UCLH/UCL Biomedical Research Centre

  • Epilepsy Research UK (OSR/0550/ERUK)

  • Clinical and Translational Science Award, Grant UL1TR002373, NIH/NCATS



  • Abe Bresver Chair in Functional Neurosurgery at the Hospital for Sick Children






Neurophysiology