Naming is Shaped by Early Facilitative and Late Compensatory Neural Interactions: an Intracranial Study of 125 Patients
Abstract number :
3.084
Submission category :
11. Behavior/Neuropsychology/Language / 11B. Pediatrics
Year :
2025
Submission ID :
224
Source :
www.aesnet.org
Presentation date :
12/8/2025 12:00:00 AM
Published date :
Authors :
Presenting Author: Ryuzaburo Kochi, MD, PhD – Wayne State University
Aya Kanno, MD, PhD – Wayne State University
Hiroshi Uda, MD, PhD – Wayne State University
Keisuke Hatano, MD, PhD – Wayne State University
Hidenori Endo, MD, PhD – Tohoku University
Michael Cools, MD – Children's Hospital of Michigan
Robert Rothermel, PhD – Wayne State University
Aimee Luat, MD – Children’s Hospital of Michigan
Eishi Asano, MD, PhD – Wayne State University
Rationale: Naming is not always performed rapidly, and competing hypotheses suggest that fast naming may reflect either enhanced or suppressed neural interactions.
Methods: Using invasive neurophysiological data from 125 neurosurgical patients, we created whole-brain Dynamic Causal Tractography atlases characterizing the local high-gamma and white matter connectivity dynamics underlying rapid and delayed auditory- and picture-naming responses, as well as sensorimotor and cognitive functions assessed via direct brain stimulation.
Results: Rapid auditory naming was associated with deactivation of the right rostral middle-frontal gyrus and increased coactivation between cortices connected through the left arcuate fasciculus, linked to stimulation-induced receptive and expressive aphasia. In contrast, delayed auditory naming correlated with a late surge in bifrontal coactivation. Rapid picture naming involved enhanced coactivation between cortices along the bilateral inferior longitudinal fasciculi, associated with stimulation-induced visual distortions, during an early period marked by co-inactivation involving Broca’s area. In summary, reduced inhibitory monitoring by the right dorsolateral prefrontal cortex may facilitate left-lateralized perisylvian pathways to expedite lexical retrieval during auditory naming. Overloaded neural interactions within bifrontal white matter networks may underlie delayed auditory naming. Rapid visual object recognition appears to rely on early occipitotemporal coactivation with minimal Broca’s area involvement.
Conclusions: Our findings identify distinct white matter–driven neural mechanisms underlying rapid versus delayed naming. These insights may improve our understanding of naming difficulties in patients with epilepsy
Funding: JSPS KAKENHI Grant Number 25K19895
NIH: R01 NS064033
Behavior