Network Coupling in Temporal Lobe Epilepsy: Relationship with Surgical Treatment Response
Abstract number :
2.3
Submission category :
9. Surgery / 9C. All Ages
Year :
2022
Submission ID :
2204432
Source :
www.aesnet.org
Presentation date :
12/4/2022 12:00:00 PM
Published date :
Nov 22, 2022, 05:25 AM
Authors :
Allen Chang, MS – Medical university Of South Carolina; Rebecca Roth, BS – Emory University; Robert Gross, MD, PhD – Emory; Irene Harmsen, PhD – University of Toronto; Alexandra Parashos, MD – Medical University of South Carolina; Andrew Revell, PhD – University of Pennsylvania; Kathryn Davis, MD, MSTR – University of Pennsylvania; Leonardo Bonilha, MD, PhD – Emory University; Ezequiel Gleichgerrcht, MD, PhD – Medical University of South Carolina
Rationale: Surgery is the most effective treatment for patients with drug-resistant temporal lobe epilepsy (TLE). Surgical outcomes are variable, and growing evidence suggests a relationship between the status of pre-surgical structural networks and surgical results. However, the relationship between structural network topology, neurophysiological/functional ictal spread, and surgical outcomes remains unclear.
Methods: We studied intracranial seizures recorded using stereoelectroencephalography (sEEG) from nine participants with TLE who subsequently underwent resective surgery. We used the stereotactic coordinates of the sEEG electrodes to construct structural (diffusion tensor imaging) and functional connectomes. A Jaccard index was used to assess the similarity (coupling) between structural and functional connectivity at multiple time points related to interictal and ictal activity.
Results: We observed that structural and functional networks exhibit significant coupling, suggesting that ictal activity follows a pattern related to structural networks. However, patients who became seizure-free after surgery had lower connectome coupling recruitment during early seizure activity than non-responders.
Conclusions: Structural networks provide a backbone for funtional activity in TLE, and lack of seizure control after surgery is associated with a stronger relationship between seizure spread patterns and structural networks.
Funding: R01NS110347 (NIH/NINDS) (L.B.)
Surgery