Neurotrophin Receptor Immunoreactivity in Severe Cerebral Cortical Dysplasia
Abstract number :
1.250
Submission category :
Year :
2000
Submission ID :
2910
Source :
www.aesnet.org
Presentation date :
12/2/2000 12:00:00 AM
Published date :
Dec 1, 2000, 06:00 AM
Authors :
Joo-Yong Kim, Sang Kun Lee, Gheeyoung Choi, Chun-Kee Chung, Kangwon National Univ, Chuncheon, South Korea; Seoul National Univ, Seoul, South Korea.
RATIONALE: Cerebral cortical dysplasia(CD) is one of the important causes of intractable epilepsies and characterized histologically by disorganized cortical lamination and cytomegalic dysplastic neurons. Although various cytoskeletal abnormalities have been found in dysplastic neurons of CD, the pathogenetic role of dysplastic neurons has rarely been investigated. METHODS: In order to know the possible relationship between dysplastic neurons with cytoskeletal abnormalities and various neurotrophin receptors, immunohistochemical analysis was performed using antibodies against NGFR p75, trkA, trkB, and trkC in surgical specimens of CD. RESULTS: TrkB and trkC were strongly expressed in dysplastic neurons of CD and NGFR p75 was also strongly expressed in some dysplastic neurons. CONCLUSIONS: Since it has been known that brain-derived neurotrophic factor(BDNF) and neurotrophin-3(NT-3) have effects on the differentiation of neuronal precursor cells from the cortex and on dendritic and axonal arborization, increased expression of trkB and trkC may play a role in cytoskeletal abnormalities and altered synaptic transmission in dysplastic neurons of CD.